Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors

被引：83

作者：

Eary, C. Todd ^{[1
]}

Jones, Zachary S. ^{[1
]}

Groneberg, Robert D. ^{[1
]}

Burgess, Laurence E. ^{[1
]}

Mareska, David A. ^{[1
]}

Drew, Mark D. ^{[1
]}

Blake, James F. ^{[1
]}

Laird, Ellen R. ^{[1
]}

Balachari, Devan ^{[1
]}

O'Sullivan, Michael ^{[1
]}

Allen, Andrew ^{[1
]}

Marsh, Vivienne ^{[1
]}

机构：

[1] Array BioPharma, Boulder, CO 80301 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 09期

关键词：

cholesteryl ester transfer protein; CETP; HDL; tetrahydoquinoxalines; cholesterol;

D O I：

10.1016/j.bmcl.2007.01.112

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterol ester between lipoprotein particles. Inhibition of this protein, in vitro and in vivo, produces an increase in plasma high density lipoprotein cholesterol (HE)L-Q. This communication will describe the SAR and svnthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors from early P lead to advanced enantiomerically pure anaiogs. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2608 / 2613

页数：6

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