Transition-Metal-Free Addition Reaction for the Synthesis of 3-(Aminobenzylidene/aminoalkylidene)indolin-2-ones and Its Synthetic Applications

被引：6
|
作者：
Bisht, Girish Singh [1 ]
Gnanaprakasam, Boopathy [1 ]
机构：
[1] Indian Inst Sci Educ & Res, Dept Chem, Pune 411008, Maharashtra, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 21期
关键词：
BETA-DICARBONYL COMPOUNDS; ONE-POT SYNTHESIS; C DOUBLE-BOND; HETEROCYCLIC SYNTHESIS; OXIDATIVE CLEAVAGE; COUPLING REACTIONS; NITRILES; EFFICIENT; ENAMINONES; KETONES;
D O I：
10.1021/acs.joc.9b01771
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient transition-metal-free approach for the exclusive synthesis of Z-3-(aminobenzylidene/aminoalkylidene)indolin-2-ones in high yield from 2-oxindole and aryl/alkyl nitrile in the presence of LiOtBu and 2,2'-bipyridine system is described. In addition, we disclosed a new approach towards the metal-free fluorination using selectfluor and the C=C bond cleavage using CuI and environmentally benign O-2.
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页码：13516 / 13527
页数：12
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