Adherence of Streptococcus pneumoniae to human bronchial epithelial cells (BEAS-2B)

被引:52
|
作者
Adamou, JE [1 ]
Wizemann, TM [1 ]
Barren, P [1 ]
Langermann, S [1 ]
机构
[1] Medimmune Inc, Dept Immunol & Mol Genet, Gaithersburg, MD 20878 USA
关键词
D O I
10.1128/IAI.66.2.820-822.1998
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Pneumococcal adherence to alveolar epithelial cells and nasopharyngeal epithelial cells has been well characterized. However, the interaction of Streptococcus pneumoniae with bronchial epithelial cells has not been studied. We have now shown that pneumococci bind specifically to a human bronchial epithelial cell line (BEAS-2B cells). Pneumococci adhered to BEAS-2B cells in a time-and dose-dependent manner. These results suggest that the bronchial epithelium may serve as an additional site of attachment for pneumococci and demonstrate the utility of the BEAS-2B cell line for studying mechanisms of pneumococcal infection.
引用
收藏
页码:820 / 822
页数:3
相关论文
共 50 条
  • [41] Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells
    Zhang, Zhuo
    Pratheeshkumar, Poyil
    Budhraja, Amit
    Son, Young-Ok
    Kim, Donghern
    Shi, Xianglin
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 456 (02) : 643 - 648
  • [42] BEAS-2B cells, a human bronchial epithelial cell line, produce C-C chemokine, MDC and TARC
    Arima, M
    Yoshida, N
    Cheng, G
    Eda, F
    Hirata, H
    Honda, K
    Fukushima, F
    Fukuda, T
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (02) : S47 - S47
  • [43] Role of LKB1 in migration and invasion of Cr(VI)-transformed human bronchial epithelial Beas-2B cells
    Lu, Jian
    Zhou, Zhongping
    Tang, Miaomiao
    Shen, Haijun
    Liu, Yi
    Wang, Jin
    Jiang, Yewen
    Chen, Yifan
    Wu, Zhanao
    ANTI-CANCER DRUGS, 2018, 29 (07) : 660 - 673
  • [44] Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells
    Lee, Yoon-Jin
    Lee, Sang-Han
    JOURNAL OF KOREAN MEDICAL SCIENCE, 2011, 26 (11) : 1474 - 1482
  • [45] The multiplex interactions and molecular mechanism on genotoxicity induced by formaldehyde and acrolein mixtures on human bronchial epithelial BEAS-2B cells
    Zhang, Sen
    Chen, Huan
    Zhang, Jingni
    Li, Jun
    Hou, Hongwei
    Hu, Qingyuan
    ENVIRONMENT INTERNATIONAL, 2020, 143
  • [46] Malignant transformation of human bronchial epithelial cells (BEAS-2B) by Cr(VI) is associated with altered mitochondria and bioenergetic phenotype
    Sampaio, A.
    Mendes, L.
    Goncalves, A. C.
    Abrantes, M.
    Sarmento, A. B.
    Botelho, F.
    Oliveira, P.
    Carvalho, R.
    Urbano, A.
    Alpoim, M. C.
    FEBS JOURNAL, 2010, 277 : 224 - 224
  • [47] Pro-inflammatory effects of extracted urban fine particulate matter on human bronchial epithelial cells BEAS-2B
    Jovile Raudoniute
    Inga Stasiulaitiene
    Ieva Kulvinskiene
    Edvardas Bagdonas
    Andrius Garbaras
    Edvinas Krugly
    Dainius Martuzevicius
    Daiva Bironaite
    Ruta Aldonyte
    Environmental Science and Pollution Research, 2018, 25 : 32277 - 32291
  • [48] Toxicogenomic study of toxic mechanism on methotrexate, amiodarone, nitrofurantoin and carbamazepine in human bronchial epithelial (BEAS-2B)
    Song, Mee
    Kim, Youn-Jung
    Ryu, Jae-Chun
    MOLECULAR & CELLULAR TOXICOLOGY, 2007, 3 (04) : 51 - 51
  • [49] Effect of N-acetylcysteine on oxidative stress in human bronchial epithelial cell line (BEAS-2B)
    Jang, G-C
    Lee, H-H
    ALLERGY, 2013, 68 : 366 - 366
  • [50] Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles
    Grilli, Andrea
    Bengalli, Rossella
    Longhin, Eleonora
    Capasso, Laura
    Proverbio, Maria Carla
    Forcato, Mattia
    Bicciato, Silvio
    Gualtieri, Maurizio
    Battaglia, Cristina
    Camatini, Marina
    BMC GENOMICS, 2018, 19 (1)