Developing High-Affinity Boron-Based Receptors for Cell-Surface Carbohydrates

被引：13

作者：

Houston, Todd A. ^{[1
]}

机构：

[1] Griffith Univ, Inst Glyc, Gold Coast, Qld 4222, Australia

来源：

CHEMBIOCHEM | 2010年 / 11卷 / 07期

关键词：

boron; boroxoles; carbohydrate binding; lectin mimics; sensors; BORIC-ACID DERIVATIVES; PHENYLBORONIC ACID; SYNTHETIC LECTIN; DIBORONIC ACID; GLUCOSE; CHEMISTRY; BINDING; MONOSACCHARIDES; CHEMOSENSORS; SACCHARIDES;

D O I：

10.1002/cbic.201000079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Chemical Equation Presented) The rich history of research into boron-carbohydrate interactions has unfortunately, not translated into many examples of boron-based receptors for cell-surface sugars. however, a recent breakthrough by Hall has shown that hexoses can be targeted with boroxele-based systems (1) that show selective binding of the TF antigen in competition with natural lectins. © 2010 Wiley-VCH Verlag GmbH& Co. KGaA.

引用

页码：954 / 957

页数：4

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