Toward the Early Detection of Cancer by Decoding the Epigenetic and Environmental Fingerprints of Cell-Free DNA

被引：206
|
作者：
van der Pol, Ymke [1 ]
Mouliere, Florent [1 ]
机构：
[1] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Dept Pathol, Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
来源：
CANCER CELL | 2019年 / 36卷 / 04期
关键词：
CIRCULATING TUMOR DNA; LIQUID BIOPSIES; PLASMA DNA; LUNG-CANCER; MITOCHONDRIAL-DNA; 5-HYDROXYMETHYLCYTOSINE SIGNATURES; PERSONALIZED MEDICINE; NONINVASIVE DETECTION; STRANDED-DNA; METHYLATION;
D O I：
10.1016/j.ccell.2019.09.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic alterations, but only a minor fraction of tumor-derived cell-free DNA (cfDNA) fragments exhibit mutations. The cellular processes occurring in cancer development mark the chromatin. These epigenetic marks are reflected by modifications in the cfDNA methylation, fragment size, and structure. In this review, we describe how going beyond DNA sequence information alone, by analyzing cfDNA epigenetic and immune signatures, boosts the potential of liquid biopsy for the early detection of cancer.
引用
收藏
页码：350 / 368
页数：19
相关论文
共 50 条
  • [41] Sensitive Quantification of Cell-Free Tumor DNA for Early Detection of Recurrence in Colorectal Cancer
    Stasik, Sebastian
    Mende, Marika
    Schuster, Caroline
    Mahler, Sandra
    Aust, Daniela
    Tannapfel, Andrea
    Reinacher-Schick, Anke
    Baretton, Gustavo
    Krippendorf, Claudia
    Bornhaeuser, Martin
    Ehninger, Gerhard
    Folprecht, Gunnar
    Thiede, Christian
    FRONTIERS IN GENETICS, 2022, 12
  • [42] Early detection of cell-free fetal DNA in maternal plasma
    Illanes, S.
    Denbow, M.
    Kailasam, C.
    Finning, K.
    Soothill, P. W.
    EARLY HUMAN DEVELOPMENT, 2007, 83 (09) : 563 - 566
  • [43] How to detect cancer early using cell-free DNA
    Hasenleithner, Samantha O.
    Speicher, Michael R.
    CANCER CELL, 2022, 40 (12) : 1464 - 1466
  • [44] Epigenetic analysis of cell-free DNA by fragmentomic profiling
    Zhou, Qing
    Kang, Guannan
    Jiang, Peiyong
    Qiao, Rong
    Lam, W. K. Jacky
    Yu, Stephanie C. Y.
    Ma, Mary-Jane L.
    Ji, Lu
    Cheng, Suk Hang
    Gai, Wanxia
    Peng, Wenlei
    Shang, Huimin
    Chan, Rebecca W. Y.
    Chan, Stephen L.
    Wong, Grace L. H.
    Hiraki, Linda T.
    Volpi, Stefano
    Wong, Vincent W. S.
    Wong, John
    Chiu, Rossa W. K.
    Chan, K. C. Allen
    Lo, Y. M. Dennis
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (44)
  • [45] Multimodal epigenetic sequencing analysis (MESA) of cell-free DNA for non-invasive colorectal cancer detection
    Li, Yumei
    Xu, Jianfeng
    Chen, Chaorong
    Lu, Zhenhai
    Wan, Desen
    Li, Diange
    Li, Jason S.
    Sorg, Allison J.
    Roberts, Curt C.
    Mahajan, Shivani
    Gallant, Maxime A.
    Pinkoviezky, Itai
    Cui, Ya
    Taggart, David J.
    Li, Wei
    GENOME MEDICINE, 2024, 16 (01)
  • [46] Multimodal epigenetic sequencing analysis (MESA) of cell-free DNA for non-invasive colorectal cancer detection
    Yumei Li
    Jianfeng Xu
    Chaorong Chen
    Zhenhai Lu
    Desen Wan
    Diange Li
    Jason S. Li
    Allison J. Sorg
    Curt C. Roberts
    Shivani Mahajan
    Maxime A. Gallant
    Itai Pinkoviezky
    Ya Cui
    David J. Taggart
    Wei Li
    Genome Medicine, 16
  • [47] Epigenetic phenotype of plasma cell-free DNA in the prediction of early-onset preeclampsia
    He, Wei
    Zhang, Yi
    Wu, Kai
    Wang, Yunan
    Zhao, Xin
    Lv, Lijuan
    Ren, Congmian
    Lu, Jiaqi
    Yang, Jiexia
    Yin, Aihua
    Liu, Guocheng
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2023, 43 (02)
  • [48] Genome-wide cell-free DNA fragmentation profiling for early cancer detection.
    Leal, Alessandro
    Cristiano, Stephen
    Phallen, Jillian
    Fiksel, Jacob
    Adleff, Vilmos
    Bruhm, Daniel C.
    Jensen, Sarah Ostrup
    Medina, Jamie E.
    Palsgrove, Doreen N.
    Niknafs, Noushin
    Anagnostou, Valsamo
    Forde, Patrick M.
    Brahmer, Julie R.
    Fijneman, Remond
    Johansen, Julia S.
    Nielsen, Hans J.
    Meijer, Gerrit A.
    Andersen, Claus Lindbjerg
    Scharpf, Robert B.
    Velculescu, Victor E.
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [49] A cell-free DNA colorectal cancer screening test promising enhanced accessibility and early detection
    Tariq, Mahsheed
    Ahmed, Mansoor
    Khan, Marwa
    Khan, Fawad
    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2024, 39 (01)
  • [50] Genome-wide mutation profiles from cell-free DNA for early cancer detection
    Nature Genetics, 2023, 55 : 1261 - 1262
12345