Highly Active Chiral Ruthenium-Based Metathesis Catalysts through a Monosubstitution in the N-Heterocyclic Carbene

被引：66

作者：

Tiede, Sascha ^{[1
]}

Berger, Anke ^{[1
]}

Schlesiger, David ^{[1
]}

Rost, Daniel ^{[1
]}

Luehl, Anja ^{[1
]}

Blechert, Siegfried ^{[1
]}

机构：

[1] Tech Univ Berlin, Inst Chem, D-10623 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 23期

关键词：

amino acids; asymmetric catalysis; N-heterocyclic carbenes; olefin metathesis; ruthenium; RING-OPENING/CROSS-METATHESIS; ASYMMETRIC OLEFIN METATHESIS; EFFICIENT ENANTIOSELECTIVE SYNTHESIS; ALKYLIDENE COMPLEXES; ALLYLIC ALKYLATION; NHC-BACKBONE; LIGANDS; DEACTIVATION; ACTIVATION;

D O I：

10.1002/anie.201000940

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equotion Present) Single (substitution) is better: New chiral ruthenium metathesis (pre)catalysts with a monosubstituted carbon atom in the N-heterocyclic carbene ligand are highly stable in solution, initiate easily, show very high enantioselectivity and excellent E selectivity in asymmetric ring-opening cross-metathesis (see scheme).© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3972 / 3975

页数：4

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