Amine-catalyzed direct aldol addition

被引：74
|
作者：
Markert, Morris [1 ]
Mulzer, Michael [1 ]
Schetter, Bernd [1 ]
Mahrwald, Rainer [1 ]
机构：
[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 23期
关键词：
D O I：
10.1021/ja071926a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient organo-catalytic, highly syn-stereoselective method for aldol additions between enolizable aldehydes and hydroxyacetone as well as dihydroxyacetone is disclosed. Reactions proceed in the presence of tertiary amines at room temperature. The aldol adducts can be obtained in good to high yields and with high degrees of syn-diastereoselectivity. This new aldol reaction provides an operationally simple protocol for the stereocontrolled synthesis of carbohydrates
引用
收藏
页码：7258 / +
页数：3
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