Neurochemical changes related to ageing in the rat brain and the effect of DL-α-lipoic acid

被引：40

作者：

Arivazhagan, P

Panneerselvam, C

机构：

[1] Univ Madras, Dept Biochem Med, Dr Al Mudaiar Post Grad Inst Basic Med Sci, Madras 600113, Tamil Nadu, India

[2] SUNY Buffalo, Dept Biochem, Buffalo, NY 14214 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2002年 / 37卷 / 12期

关键词：

neurotransmitters; ageing and DL-alpha-lipoic acid;

D O I：

10.1016/S0531-5565(02)00122-5

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Age-related impairments of cognitive and motor function have been linked to a number of deleterious morphological and functional changes involving different areas of the brain. Loss of neurotransmitters, their receptors and responsiveness to neurotransmitters are key manifestations of neurological ageing and age-related disorders. In the present investigation we have evaluated the effect of DL-alpha-lipoic acid on neurotransmitters in discrete brain regions of young and aged rats. The levels of neurotransmitters were found to be lowered in aged rats. Moreover, DL-alpha-lipoic acid treated aged rats showed a increase in the status of dopamine, serotonin and norepinephrine. The results of this study provide evidence that DL-alpha-lipoic acid (a potent antioxidant) treatment can improve neurotransmitters during ageing. Hence, it can be concluded that DL-alpha-lipoic acid act as a potent neuromodulator in the brain of aged rats. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：1489 / 1494

页数：6

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