Background: Saudi females constitute less than 5% of blood donors and as demand for blood is ever increasing there is a need to identify the factors that discourage them from donating their blood and subsequently to find approaches to enhance their share as blood donors. The aim of this study is to find out the knowledge, attitude and motivation of Saudi female university students towards blood donation. Methods: This is a questionnaire-based cross-sectional descriptive study among female students (n = 300) from six colleges: Medicine, Dentistry, Applied Medical Sciences, Science, Arts, and Business Administration at King Saud University, Riyadh. Questions covered their knowledge on blood donation and factors that discourage or motivate them to donate. Results: The majority of participants are unaware that females constitute less than 5% of donors, but know that blood banks are in continuous need for donors to give support for needy patients particularly road traffic accidents and surgical patients. Fear from complications of the donation process prevailed widely. Most participants would donate as a religious obligation, need of a relative or friend, but not for money. The most prominent hurdle preventing them from donating is the difficulty of reaching the blood bank as they cannot drive cars or move alone in public transport. Most will donate if blood collection is done at their colleges and other places of gathering such as shopping malls. Conclusions: The attitude of Saudi female students towards blood donation is positive and few misconceptions that emerged could be corrected by health awareness campaigns. Careful organization of blood collection efforts that would observe the special status of women in the society by reaching them in their colleges and other gathering sites could enhance female donor input markedly.
