Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients

被引：13

作者：

Watson, Stuart ^{[1
]}

Gallagher, Peter ^{[1
]}

Smith, Margaret S. ^{[1
]}

Young, Allan H. ^{[1
]}

Ferrier, I. Nicol ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Sch Neurol Neurobiol & Psychiat, Stanley Res Ctr, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

PSYCHONEUROENDOCRINOLOGY | 2007年 / 32卷 / 05期

关键词：

lithium; argipressin; bipolar disorder; major depressive disorder; hypothalamic-pituitary-adrenal axis; Dex/CRH test;

D O I：

10.1016/j.psyneuen.2007.02.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The impact of lithium on arginine vasopressin (AVP) release has implications for our understanding of the pathophysiology and treatment of mood disorders and for the interpretation of neuroendocrine studies. In this secondary analysis of neuroendocrine, data from 23 patients with chronic major depressive disorder, 41 patients with bipolar disorder and 18 healthy controls, we examine the relationship between lithium therapy, AVP levels and the cortisol response to the dexamethasone/corticotropin-releasing hormone (dex/CRH) test. These data demonstrate that patients taking lithium have elevated post-dexamethasone AVP levels compared to both healthy controls and patients not on lithium. (C) 2007 Elsevier Ltd. Alt rights reserved.

引用

页码：464 / 469

页数：6

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