DNA ligase: Getting a grip to seal the deal

被引：16

作者：

Johnson, A

O'Donnell, M

机构：

[1] Howard Hughes Med Inst, New York, NY 10021 USA

[2] Rockefeller Univ, New York, NY 10021 USA

来源：

CURRENT BIOLOGY | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.cub.2005.01.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of human DNA ligase I catches the enzyme just before the last step of ligation and shows that the protein wraps completely around nicked DNA. The elegant structure explains how ligase attains fidelity for the sealing operation.

引用

页码：R90 / R92

页数：3

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