Osteopontin in Cardiovascular Disease A Potential Therapeutic Target

被引：80

作者：

Waller, Alfonso H. ^{[1
]}

Sanchez-Ross, Monica ^{[1
]}

Kaluski, Edo ^{[1
]}

Klapholz, Marc ^{[1
]}

机构：

[1] UMDNJ, New Jersey Med Sch, Div Cardiol, Dept Med, Newark, NJ 07103 USA

来源：

CARDIOLOGY IN REVIEW | 2010年 / 18卷 / 03期

关键词：

osteopontin; myocardial infarction; heart failure; calcification; valvular disease; myocardial remodeling; MICROVASCULAR ENDOTHELIAL-CELLS; LEFT-VENTRICULAR DILATION; ANGIOTENSIN-II; PLASMA OSTEOPONTIN; MYOCARDIAL-INFARCTION; MESSENGER-RNA; ATHEROSCLEROTIC LESIONS; BONE SIALOPROTEIN; CARDIAC FIBROSIS; HEART-FAILURE;

D O I：

10.1097/CRD.0b013e3181cfb646

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Osteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a multifunctional protein. OPN has been found to be expressed in various cell types and species with many physiologic and pathologic functions. OPN has emerged as a potential biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of OPN in cardiovascular disease, specifically in vascular and valvular heart disease, myocardial infarction and heart failure.

引用

页码：125 / 131

页数：7

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