Drug-Antibody Ratio of an Antibody-Drug Conjugate by SEC-MALS

被引:0
|
作者
不详
机构
关键词
D O I
暂无
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Drug-antibody ratio (DAR) is a critical attribute of antibody-drug conjugates (ADCs). DAR may often be determined quickly and effectively by combining SEC with three online detectors: MALS, UV, and dRI.
引用
收藏
页码:420 / 420
页数:1
相关论文
共 50 条
  • [21] Antibody-drug conjugate for ovarian cancer
    Collingridge, David
    LANCET ONCOLOGY, 2020, 21 (07): : 886 - 886
  • [22] Year in review: Antibody-drug conjugate
    Sato, Jun
    CANCER SCIENCE, 2024, 115 : 1459 - 1459
  • [23] Antibody-Drug Conjugate to Treat Meningiomas
    Chen, Kai
    Si, Yingnan
    Ou, Jianfa
    Guan, Jia-Shiung
    Kim, Seulhee
    Ernst, Patrick
    Zhang, Ya
    Zhou, Lufang
    Han, Xiaosi
    Liu, Xiaoguang
    PHARMACEUTICALS, 2021, 14 (05)
  • [24] Antibody-drug conjugate drug development: where are the challenges?
    Wright, Laura
    Baughman, Sharon
    Wake, Ashleigh
    BIOANALYSIS, 2013, 5 (12) : 1467 - 1469
  • [25] A rapid approach for characterization of thiol-conjugated antibody-drug conjugates and calculation of drug-antibody ratio by liquid chromatography mass spectrometry
    Firth, David
    Bell, Leonard
    Squires, Martin
    Estdale, Sian
    McKee, Colin
    ANALYTICAL BIOCHEMISTRY, 2015, 485 : 34 - 42
  • [26] DRUG-ANTIBODY COMPLEXES FOR IMMUNOTHERAPY
    PIETERSZ, GA
    KANELLOS, J
    SMYTH, M
    MCKENZIE, IFC
    BRITISH JOURNAL OF CANCER, 1985, 52 (04) : 664 - 664
  • [27] Pharmacist Involvement in Antibody-Drug Conjugate Therapy
    Mishiyeva, Oksana
    Farina, Kyle A.
    Rattu, Mohammad A.
    US PHARMACIST, 2022, 47 (01) : 34 - 55
  • [28] Antibody-drug Conjugate Targets, Drugs, and Linkers
    Teicher, Beverly A.
    Morris, Joel
    CURRENT CANCER DRUG TARGETS, 2022, 22 (06) : 463 - 529
  • [29] Stepping forward in antibody-drug conjugate development
    Jin, Yiming
    Schladetsch, Megan A.
    Huang, Xueting
    Balunas, Marcy J.
    Wiemer, Andrew J.
    PHARMACOLOGY & THERAPEUTICS, 2022, 229
  • [30] Photoinduced Aggregation of a Model Antibody-Drug Conjugate
    Cockrell, Gregory M.
    Wolfe, Michael S.
    Wolfe, Janet L.
    Schoeneich, Christian
    MOLECULAR PHARMACEUTICS, 2015, 12 (06) : 1784 - 1797