The isometric path cover (partition) problem of a graph consists of finding a minimum set of isometric paths which cover (partition) the vertex set of the graph. The isometric path cover (partition) number of a graph is the cardinality of a minimum isometric path cover (partition). We prove that the isometric path partition problem and the isometric k-path partition problem for k >= 3 are NP-complete on general graphs. Fisher and Fitzpatrick in [The isometric number of a graph, J. Combin. Math. Combin. Comput. 38 (2001) 97{110] have shown that the isometric path cover number of the (r x r)-dimensional grid is [2r/3] We show that the isometric path cover (partition) number of the (r x s)-dimensional grid is s when r >= s(s - 1). We establish that the isometric path cover (partition) number of the (r x r)-dimensional torus is r when r is even and is either r or r + 1 when r is odd. Then, we demonstrate that the isometric path cover (partition) number of an r-dimensional Benes network is 2(r). In addition, we provide partial solutions for the isometric path cover (partition) problems for cylinder and multi-dimensional grids. We apply two different techniques to achieve these results.