Religion, spirituality, and lesbian, gay, bisexual, transgender, and queer (LGBTQ+) studies have a complicated history between them and several points of both divergence and convergence as well as outright conflict. Despite this challenging history, recent efforts to explore the intersection of religion, spirituality, and LGBTQ+ studies are promising, as psychologically meaningful questions are raised and studied. The central focus of this special issue of Spirituality in Clinical Practice is to challenge psychologists in the psychology of religion and spirituality and in LGBTQ+ studies to consider the intersection of these historically complex areas of research, investigation, and clinical practice. This is a joint publication with Psychology of Religion and Spirituality, which will publish a special section later this summer.