The use of antisence oligonucleotides for modulation of cytokine gene expression.

被引：0

作者：

Kozlov, VA ^{[1
]}

Sennikov, SV ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Clin Immunol, Siberian Branch, Novosibirsk 630099, Russia

来源：

VOPROSY MEDITSINSKOI KHIMII | 1997年 / 43卷 / 05期

关键词：

antisense oligonucleotides; modulation of cytokine gene expression; haemopoesis; immunopoesis;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The review summarizes literature data on the mechanism of action and the use of antisence oligonucleotides for modulation of cytokine gene expression in haemo- and immunopoesis. This new approach for gene-directed modulation of the gene expression allows to analyze both intercellular and intracellular protein interaction. Use of this approach is prospective for both experimental researches in vivo and in vitro and application in therapeutic purposes.

引用

页码：308 / 320

页数：13

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