Where do they come from? Insights into autophagosome formation

被引：79
|
作者：
Hamasaki, Maho [1 ]
Yoshimori, Tamotsu [1 ]
机构：
[1] Osaka Univ, Microbial Dis Res Inst, Dept Cellular Regulat, Suita, Osaka 5650871, Japan
来源：
FEBS LETTERS | 2010年 / 584卷 / 07期
关键词：
Autophagy; Membrane biogenesis; Endoplasmic reticulum; Beclin-1; Atg14p; PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES; YEAST SACCHAROMYCES-CEREVISIAE; BECLIN 1-DEPENDENT AUTOPHAGY; ENDOPLASMIC-RETICULUM; ISOLATION MEMBRANES; INDUCED AUTOPHAGOCYTOSIS; REGULATES AUTOPHAGY; ELECTRON-MICROSCOPY; SECRETORY PATHWAY; RAT HEPATOCYTES;
D O I：
10.1016/j.febslet.2010.02.061
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Autophagosomes (APs) are unique organelles that enwrap cytoplasmic components when necessary. APs then fuse with lysosomes and enclosed materials are degraded. Although approximately 30 autophagy-related genes (ATG) required for AP formation have been identified, fundamental questions on the membrane source or dynamics during the formation remain unresolved. Here, we present a comprehensive overview of the putative membrane sources identified to date. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：1296 / 1301
页数：6
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