Influence of type 2 diabetes mellitus on liver histology among morbidly obese individuals. A cross-sectional study

被引:9
|
作者
Cazzo, Everton [1 ]
Jimenez, Laisa Simakawa [1 ]
Gallo, Fabio de Felice [1 ]
Pareja, Jose Carlos [1 ]
Chaim, Elinton Adami [1 ]
机构
[1] Univ Estadual Campinas Unicamp, Dept Surg, Sao Paulo, Brazil
来源
SAO PAULO MEDICAL JOURNAL | 2016年 / 134卷 / 01期
关键词
Fatty liver; Insulin resistance; Diabetes mellitus; Bariatric surgery; Obesity; Y GASTRIC BYPASS; NAFLD FIBROSIS SCORE; FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS; BARIATRIC SURGERY; CARDIOVASCULAR-DISEASE; CLINICAL-IMPLICATIONS; PATHOPHYSIOLOGY; BIOPSY; RISK;
D O I
10.1590/1516-3180.2015.01652409
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
CONTEXT AND OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) has become a public health concern. It encompasses a wide spectrum of histological abnormalities and has close relationships with insulin resistance and type 2 diabetes mellitus (T2DM). This study sought to compare the histological alterations observed in morbidly obese individuals with and without T2DM who underwent Roux-en-Y gastric bypass. DESIGN AND SETTING: Cross-sectional study in a tertiary-level public hospital. METHODS: This was a cross-sectional study on 197 individuals who underwent gastric bypass surgery between 2011 and 2013. NAFLD was assessed through liver biopsies. T2DM was diagnosed through the International Diabetes Federation criteria. RESULTS: Non-diabetics presented significantly more biopsies without any histological abnormalities, regarding steatosis (42.6% versus 25.5%; P = 0.0400), fibrosis (60.6% versus 36.2%; P = 0.0042) and steatohepatitis (27.3% versus 12.8%; P = 0.0495), while diabetics presented significantly higher frequency of moderate forms of steatosis (36.2% versus 20%; P = 0.0307) and fibrosis (23.4% versus 4%; P = 0.0002). DISCUSSION: T2DM was associated with more advanced forms of NAFLD within the population studied. NAFLD has previously been correlated with severe forms of heart disease. CONCLUSION: Screening for and early detecting of NAFLD in high-risk populations are important for avoiding further development of severe forms and the need for liver transplantation.
引用
收藏
页码:79 / 83
页数:5
相关论文
共 50 条
  • [21] Eating behavior among persons with type 2 diabetes mellitus in North Ethiopia: a cross-sectional study
    Gebreyesus, Hagos Amare
    Abreha, Girmatsion Fisseha
    Besherae, Sintayehu Degu
    Abera, Merhawit Atsbha
    Weldegerima, Abraha Hailu
    Kidane, Eshetu Girma
    Bezabih, Afework Mulugeta
    Lemma, Tefera Belachew
    Nigatu, Tsinuel Girma
    BMC ENDOCRINE DISORDERS, 2021, 21 (01)
  • [22] ANALYSIS OF PHYSICAL ACTIVITY PATTERNS AMONG TYPE-2 DIABETES MELLITUS: A CROSS-SECTIONAL STUDY
    Kaur, Khushwant
    Sandhu, Jaspal Singh
    INTERNATIONAL JOURNAL OF PHYSIOTHERAPY, 2015, 2 (02) : 392 - 398
  • [23] Association of glycemic control and anthropometric measurement among type 2 diabetes mellitus: a cross-sectional study
    Taderegew, Mitku Mammo
    Emeria, Mamo Solomon
    Zegeye, Betregiorgis
    DIABETOLOGY INTERNATIONAL, 2021, 12 (04) : 356 - 363
  • [24] Association of glycemic control and anthropometric measurement among type 2 diabetes mellitus: a cross-sectional study
    Mitku Mammo Taderegew
    Mamo Solomon Emeria
    Betregiorgis Zegeye
    Diabetology International, 2021, 12 : 356 - 363
  • [25] Type 2 diabetes mellitus among government employees in Harar, Eastern Ethiopia: a cross-sectional study
    Ayana, Desalegn Admassu
    Bacha, Yadeta Dessie
    Roba, Kedir Teji
    Kebede, Dawit Ayele
    RESEARCH AND REPORTS IN ENDOCRINE DISORDERS, 2015, 5 : 71 - 77
  • [26] Medication Adherence and its Predictors among Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study
    Sharma, Deepak
    Goel, Naveen Krishan
    Cheema, Yuvraj Singh
    Garg, Keshav
    INDIAN JOURNAL OF COMMUNITY MEDICINE, 2023, 48 (05) : 781 - 785
  • [27] Self-care activities among patients with type 2 diabetes mellitus: A cross-sectional study
    Tang, Jiao
    Wu, Tingting
    Hu, Xiling
    Gao, Lingling
    INTERNATIONAL JOURNAL OF NURSING PRACTICE, 2021, 27 (06)
  • [28] Shoulder pain among type 2 diabetes mellitus patients: A cross-sectional study in Chilean population
    Habechian, Fernanda A. P.
    Flores-Quezada, Mauricio Esteban
    Martinez-Ortega, Anais Catalina
    Cuevas-Cid, Rodrigo Ignacio
    Zanca, Gisele Garcia
    PRIMARY CARE DIABETES, 2025, 19 (02) : 190 - 194
  • [29] Health Technology Readiness Profiles Among Danish Individuals With Type 2 Diabetes: Cross-Sectional Study
    Thorsen, Ida Kaer
    Rossen, Sine
    Glumer, Charlotte
    Midtgaard, Julie
    Ried-Larsen, Mathias
    Kayser, Lars
    JOURNAL OF MEDICAL INTERNET RESEARCH, 2020, 22 (09)
  • [30] Influence of age on static postural control in adults with type 2 diabetes mellitus: a cross-sectional study
    Zhuang, Yujun
    Hong, Zhenzhen
    Wu, Lijuan
    Zou, Chunyan
    Zheng, Yan
    Chen, Liming
    Yin, Lianhua
    Qin, Jiawei
    FRONTIERS IN ENDOCRINOLOGY, 2023, 14