Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

被引：10

作者：

Kim, Nahyun ^{[1
]}

Cho, Kyu-Won ^{[1
]}

Hong, Seong Su ^{[1
,2
]}

Hwang, Bang Yeon ^{[3
]}

Chun, Taehoon ^{[1
]}

Lee, Dongho ^{[1
]}

机构：

[1] Korea Univ, Coll Life Sci & Biotechnol, Seoul 136713, South Korea

[2] Gyeonggi Inst Sci & Technol Promot, Inst Nat Prod Res, Suwon 443270, South Korea

[3] Chungbuk Natl Univ, Coll Pharm, Cheongju 362763, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Dictamnus dasycarpus; Rutaceae; Glabretal-type triterpenoid; Antiproliferative effect; TIRUCALLANE TRITERPENOIDS; CYCLOSPORINE-A; CONSTITUENTS; ALKALOIDS; APOTIRUCALLANE; GLYCOSIDES; ALBUS; ACIDS;

D O I：

10.1016/j.bmcl.2014.12.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：621 / 625

页数：5

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