Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

被引：10
|
作者：
Kim, Nahyun [1 ]
Cho, Kyu-Won [1 ]
Hong, Seong Su [1 ,2 ]
Hwang, Bang Yeon [3 ]
Chun, Taehoon [1 ]
Lee, Dongho [1 ]
机构：
[1] Korea Univ, Coll Life Sci & Biotechnol, Seoul 136713, South Korea
[2] Gyeonggi Inst Sci & Technol Promot, Inst Nat Prod Res, Suwon 443270, South Korea
[3] Chungbuk Natl Univ, Coll Pharm, Cheongju 362763, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Dictamnus dasycarpus; Rutaceae; Glabretal-type triterpenoid; Antiproliferative effect; TIRUCALLANE TRITERPENOIDS; CYCLOSPORINE-A; CONSTITUENTS; ALKALOIDS; APOTIRUCALLANE; GLYCOSIDES; ALBUS; ACIDS;
D O I：
10.1016/j.bmcl.2014.12.007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：621 / 625
页数：5
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