Localization of denaturation bubbles in random DNA sequences

被引：74

作者：

Hwa, T ^{[1
]}

Marinari, E

Sneppen, K

Tang, LH

机构：

[1] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Ctr Theoret Biol Phys, La Jolla, CA 92093 USA

[3] Univ Roma La Sapienza, Ist Nazl Fis Mat, I-00185 Rome, Italy

[4] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy

[5] Niels Bohr Inst, DK-2100 Copenhagen, Denmark

[6] Hong Kong Baptist Univ, Dept Phys, Kowloon, Hong Kong, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 08期

关键词：

D O I：

10.1073/pnas.0736291100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We study the thermodynamic and dynamic behaviors of twist-induced denaturation bubbles in a long, stretched random sequence of DNA. The small bubbles associated with weak twist are delocalized. Above a threshold torque, the bubbles of several tens of bases or larger become preferentially localized to AT-rich segments. In the localized regime, the bubbles exhibit "aging" and move around subdiffusively with continuously varying dynamic exponents. These properties are derived by using results of large-deviation theory together with scaling arguments and are verified by Monte Carlo simulations.

引用

页码：4411 / 4416

页数：6

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