Comparison of autologous serum and umbilical cord serum eye drops for dry eye syndrome

PURPOSE: To compare the therapeutic effect between autologous serum and umbilical cord serum eye drops in the treatment of severe dry eye syndrome. DESIGN: Prospective case-control study. METHODS: Ninety-two eyes of 48 patients with severe dry eye syndrome (34 eyes of 17 patients with Sjogren syndrome and 58 eyes of 31 patients with non,Sjogren syndrome) were treated with either 20% autolo- gous serum (41 eyes of 21 patients) or umbilical cord serum eye drops (51 eyes of 27 patients). Symptom scoring, corneal sensitivity test, tear film break-up time (BUT), Schirmer test, tear clearance rate (TCR), corneal fluorescein staining, and conjunctival impression cytologic analysis were performed before and one month and two months after treatment. RESULTS: Both autologous serum and umbilical serum treatments led to improvement in the symptom score, tear film BUT, keratoepitheliopathy score, and impres- sion cytologic findings. Symptom and keratoepitheliopa, thy scores were lower at one month (P = .03 and P = .12) and two months (P = .04 and .02) for those treated with umbilical cord serum compared with those treated with autologous serum. In Sjogren syndrome patients, goblet cell density was higher at two months of umbilical cord serum treatment compared with autologous serum treatment (P = .04). CONCLUSIONS: Umbilical cord serum eye drops were more effective in decreasing symptoms and keratoepitheliopathy in severe dry eye syndrome and increasing goblet cell density in Sjogren syndrome compared with autologous serum eye drops.