Genetic heterogeneity and clonal evolution in acute myeloid leukemia

被引：14
|
作者：
Romer-Seibert, Jennifer S. [1 ]
Meyer, Sara E. [1 ]
机构：
[1] Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Dept Canc Biol, Bluemle Life Sci Bldg,Suite 319,233 S 10th St, Philadelphia, PA 19107 USA
来源：
CURRENT OPINION IN HEMATOLOGY | 2021年 / 28卷 / 01期
关键词：
acute myeloid leukemia; clonal dynamics; clonal evolution; single-cell sequencing; tumor heterogeneity;
D O I：
10.1097/MOH.0000000000000626
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of review Clonal heterogeneity is a significant obstacle to successful treatment of patients with acute myeloid leukemia (AML). Here, we review new advances in the understanding of genetic heterogeneity in AML using single-cell DNA-sequencing technology. Recent findings New genomics and immunologic discovery tools have provided single-cell resolution maps of the clonal architecture of AML. The use of these technologies reveals the mutational landscape of AML at diagnosis, during treatment, and at relapse has an enormous degree of clonal complexity and diversity that is poised to adapt and evolve under environmental pressures. AML is a complex ecosystem of competing and cooperating clones undergoing constant evolution and selection.
引用
收藏
页码：64 / 70
页数：7
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