Graphene as multifunctional delivery platform in cancer therapy

被引:41
|
作者
Nejabat, Mojgan [1 ]
Charbgoo, Fahimeh [2 ]
Ramezani, Mohammad [2 ,3 ]
机构
[1] Mashhad Univ Med Sci, Dept Med Chem, Fac Pharm, Mashhad, Iran
[2] Mashhad Univ Med Sci, Dept Pharmaceut Biotechnol, Fac Pharm, Mashhad, Iran
[3] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Mashhad, Iran
关键词
graphene; graphene oxide; drug delivery; gene delivery; targeting; MESENCHYMAL STEM-CELLS; AUTOLOGOUS CHONDROCYTE IMPLANTATION; ARTICULAR-CARTILAGE DEFECTS; RANDOMIZED CONTROLLED-TRIAL; TOTAL KNEE ARTHROPLASTY; IN-VITRO; INTRAARTICULAR INJECTION; ARTHROSCOPIC MICROFRACTURE; OSTEOARTHRITIC KNEES; EXTRACELLULAR-MATRIX;
D O I
10.1002/jbm.a.36080
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The biomedical applications of graphene-based nanomaterials including drug and gene delivery have grown rapidly in the past few years. This is due to its high surface area that results in high cargo loading capacity. It is demonstrated that graphene can improve drug efficacy without increasing the dose of the chemotherapeutic agent in cancer treatment. Considering these valuable benefits of graphene, this review focused on the newest advancements in drug and gene delivery systems using graphene and unveiling advantages and disadvantages of different graphene-based materials in introducing an effective cargo delivery system for cancer therapy. Different approaches for reducing cytotoxic impacts of graphene oxide and production of biocompatible delivery platform were also reviewed. (C) 2017 Wiley Periodicals, Inc.
引用
收藏
页码:2355 / 2367
页数:13
相关论文
共 50 条
  • [11] A multifunctional nanomedicine platform for co-delivery of methotrexate and mild hyperthermia towards breast cancer therapy
    Ong, Yong Sze
    Banobre-Lopez, Manuel
    Costa Lima, Sofia A.
    Reis, Salette
    MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 116
  • [12] Graphene oxide: A promising platform for delivery of cancer immunotherapy
    Chattrakarn, S.
    Mallett, G.
    Zhang, W.
    Parker, H.
    Kostarelos, K.
    MacDonald, A.
    ANNALS OF ONCOLOGY, 2023, 34 : S1156 - S1156
  • [13] Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy
    Gindy, Marian E.
    Prud'homme, Robert K.
    EXPERT OPINION ON DRUG DELIVERY, 2009, 6 (08) : 865 - 878
  • [14] Multifunctional Nanomaterials and Their Applications in Drug Delivery and Cancer Therapy
    Srinivasan, Mathangi
    Rajabi, Mehdi
    Mousa, Shaker A.
    NANOMATERIALS, 2015, 5 (04) : 1690 - 1703
  • [15] Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
    Guo, Xing
    Wei, Xiao
    Chen, Zi
    Zhang, Xiaobin
    Yang, Guang
    Zhou, Shaobing
    PROGRESS IN MATERIALS SCIENCE, 2020, 107
  • [16] Nano-Graphene Oxide: A Potential Multifunctional Platform for Cancer Therapy (vol 2, pg 1072, 2013)
    Goncalves, Gil
    Vila, Mercedes
    Portoles, Maria-Teresa
    Vallet-Regi, Maria
    Gracio, Jose
    Marques, Paula Alexandrina A. P.
    ADVANCED HEALTHCARE MATERIALS, 2014, 3 (07) : 956 - 956
  • [17] Multifunctional Mixed Micelles for Efficient Docetaxol Delivery for Cancer Therapy
    Zhang, Pei
    He, Wenxiu
    Zhang, Huiyuan
    Huang, Chunzhi
    Zhao, Dujuan
    Luan, Yuxia
    CHEMPLUSCHEM, 2016, 81 (11): : 1237 - 1244
  • [18] Design of Multifunctional Nanocarriers for Delivery of Anti-Cancer Therapy
    Mehra, Neelesh Kumar
    Jain, Keerti
    Jain, Narendra Kumar
    CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (42) : 6157 - 6164
  • [19] Multifunctional nanoemulsions for intraductal delivery as a new platform for local treatment of breast cancer
    Migotto, Amanda
    Carvalho, Vanessa F. M.
    Salata, Giovanna C.
    da Silva, Fernanda W. M.
    Yan, Chao Yun Irene
    Ishida, Kelly
    Costa-Lotufo, Leticia V.
    Steiner, Alexandre A.
    Lopes, Luciana B.
    DRUG DELIVERY, 2018, 25 (01) : 654 - 667
  • [20] Exosomes and mimics as novel delivery platform for cancer therapy
    Yang, Fuxu
    Wang, Mingyue
    Guan, Xingang
    FRONTIERS IN PHARMACOLOGY, 2022, 13