5-Fluorouracil derivatives - XXIII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils having aromatic ring

被引：0
|
作者：
Ozaki, S [1 ]
Kong, XZ
Watanabe, Y
Hoshiko, T
Ogasawara, T
Ueno, T
Furukawa, U
Iigo, M
Hoshi, A
机构：
[1] Shandong Univ, Dept Chem, Jinan 250100, Shandong, Peoples R China
[2] Ehime Univ, Fac Engn, Dept Appl Chem, Mastuyama 790, Japan
[3] Natl Canc Ctr, Res Inst, Chuo Ku, Tokyo 104, Japan
来源：
CHINESE JOURNAL OF CHEMISTRY | 1998年 / 16卷 / 02期
关键词：
antitumor agent; aromatic carbamoyl-5-fluorouracil; 1-(p-methoxybenzyl)-6-fluorouracil; 1-(p-iso-propylbenzyl)-5-fluorouracil;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In order to get good antitumor agents especially better than 5-fluorouracil, tegafur and 1-hexylcarbamoyl-5-fluorouracil (HCFU), fourty nine 1-carbamoyl-5-fluorouracil having aromatic ring were synthesized from 5-fluorouracil acid isocyanates or amines. Antitumor activity was tested in the L-1210 tumor system, and 5 compounds gave better value of therapeutic ratio than Ei-fluorouracil, tegafur, HCFU, 1-(4-Methoxybenzylcarbamoyl)-5-fluorouracil gave the best result.
引用
收藏
页码：171 / 177
页数：7
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