Gemcitabine and UFT plus oral calcium folinate: Phase I study

被引：0
|
作者：
Philip, PA [1 ]
Ibrahim, D [1 ]
Zalupski, M [1 ]
Arlauskas, P [1 ]
Shields, A [1 ]
机构：
[1] Wayne State Univ, Barbara Ann Karmanos Canc Inst, Div Hematol & Oncol, Detroit, MI 48201 USA
来源：
ONCOLOGY-NEW YORK | 1999年 / 13卷 / 07期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gemcitabins (Gemzar) is a nucleoside analog increasingly used in the treatment of a variety of solid tumors. DNA synthesis is inhibited by gemcitabine by masked chain termination and via inhibition of ribonucleotide reductase. Synergy may exist between gemcitabine and other antimetabolites, including 5-fluorouracil. The varying patterns of dose-limiting toxicities to gemcitabine and UFT (uracil and tegafur in a 4:1 molar ratio) plus oral calcium folinate (Orzel) permit their use in combination. The primary aint of this phase I study is to determine the maximum tolerated doses of gemcitabine and UFT plus oral calcium folinate irt patients with a variety of solid tumors. Only eight patients have been recruited to date,,vith myelosuppression being the main toxicity observed.
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页码：116 / 119
页数：4
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