Activity of a Novel 1,3-Beta-D-Glucan Synthase Inhibitor, Ibrexafungerp (Formerly SCY-078), against Candida glabrata

被引：25

作者：

Ghannoum, M. ^{[1
,2
]}

Long, L. ^{[1
,2
]}

Isham, N. ^{[1
,2
]}

Hager, C. ^{[1
,2
]}

Wilson, R. ^{[1
,2
]}

Borroto-Esoda, K. ^{[3
]}

Barat, S. ^{[3
]}

Angulo, D. ^{[3
]}

机构：

[1] Case Western Reserve Univ, Ctr Med Mycol, Cleveland, OH 44106 USA

[2] Univ Hosp Cleveland Med Ctr, Cleveland, OH 44106 USA

[3] Scynexis Inc, Jersey City, NJ USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 12期

关键词：

Candida glabrata; fks mutation; ibrexafungerp; MK-3118;

D O I：

10.1128/AAC.01510-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ibrexafungerp (formerly SCY-078), a novel glucan synthase inhibitor with oral availability, was evaluated for activity against Candida glabrata. The susceptibility of clinical strains to ibrexafungerp was determined by microdilution and time-kill assays. The MIC range against wild-type strains was 1 to 2 mu g/ml. Ibrexafungerp was also active against the majority of echinocandin-resistant strains. Time-kill studies showed 4- to 6-log-unit reductions in growth at 24 and 48 h with concentrations of 0.25 to 4 mu g/ml.

引用

页数：3

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