Can molecular mimicry explain the cytokine storm of SARS-CoV-2?: An in silico approach

被引：12
|
作者：
Obando-Pereda, Gustavo [1 ]
机构：
[1] Univ Catolica Santa Maria, Prote Inflammat & Pain Lab, Urb San Jose S-N, Arequipa 04001, Peru
来源：
JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 09期
关键词：
cytokine storm; macrophage; molecular mimicry; SARS-CoV-2; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; MACROPHAGE ACTIVATION; CD8(+) T; COVID-19; PROTEIN; PARP14; SEQUENCE; PEPTIDE;
D O I：
10.1002/jmv.27040
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients.
引用
收藏
页码：5350 / 5357
页数：8
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