Impacts of Mercury Exposure Levels and Sources on the Demethylation of Methylmercury Through Human Gut Microbiota

被引:7
|
作者
Yang, Xian-Feng [1 ]
Yang, Shao-Chen [2 ]
Wen, Fu-Li [1 ]
Feng, Lin [3 ]
Meng, Bo [3 ]
Hu, Hai-Yan [3 ]
Wang, Bao-Lin [3 ]
Li, Jun [1 ]
Poulain, Alexandre J. [4 ]
Li, Ping [1 ,3 ]
机构
[1] Guizhou Med Univ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang 550025, Peoples R China
[2] China Univ Geosci, Sch Earth Sci, Hubei Key Lab Crit Zone Evolut, Wuhan 430074, Peoples R China
[3] Chinese Acad Sci, Inst Geochem, State Key Lab Environm Geochem, Guiyang 550081, Peoples R China
[4] Univ Ottawa, Fac Sci, Dept Biol, Ottawa, ON K1N 6N5, Canada
基金
中国国家自然科学基金;
关键词
Methylmercury; Demethylation; Gut microbiota; Exposure level; Exposure source; HUMAN-BODY BURDEN; METABOLISM; CHINA; RICE; FISH;
D O I
10.1007/s00128-022-03569-5
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
This study aims to investigate methylmercury (MeHg) demethylation processes in human gut. Here, we determined the compositions and MeHg demethylation rates of gut microbiota in residents from different Hg exposure levels (Wanshan (WS) town and Yangtou (YT) town) and different Hg exposure sources (Zhuchang (ZC) town and YT town) regions. MeHg and inorganic Hg exposure levels in residents of WS town were significantly higher than those of YT and ZC town. Desulfovibrio and Methanogens, which related to Hg methylation/demethylation, showed significantly higher abundance in WS and ZC, comparing with YT. In vitro experiments demonstrated that human intestinal microbiota could degrade MeHg directly. Besides, gut microbiota in WS and ZC exhibited significantly higher demethylation rates than YT, suggesting Desulfovibrio and Methanogens may play important roles in intestinal MeHg demethylation. This study highlights Hg exposure levels and sources may affect demethylation efficiency of gut microbiota, which provides new insights for MeHg demethylation processes in human body.
引用
收藏
页码:534 / 541
页数:8
相关论文
共 50 条
  • [21] Influence of perinatal and childhood exposure to tobacco and mercury in children's gut microbiota
    Perez-Castro, Sonia
    D'Auria, Giuseppe
    Llambrich, Maria
    Fernandez-Barres, Silvia
    Lopez-Espinosa, Maria-Jose
    Llop, Sabrina
    Regueiro, Benito
    Bustamante, Mariona
    Francino, M. Pilar
    Vrijheid, Martine
    Maitre, Lea
    FRONTIERS IN MICROBIOLOGY, 2024, 14
  • [22] Nitric Oxide Impacts Human Gut Microbiota Diversity and Functionalities
    Leclerc, Marion
    Bedu-Ferrari, Cassandre
    Etienne-Mesmin, Lucie
    Mariadassou, Mahendra
    Lebreuilly, Lucie
    Tran, Seav-Ly
    Brazeau, Laurence
    Mayeur, Camille
    Delmas, Julien
    Rue, Olivier
    Denis, Sylvain
    Blanquet-Diot, Stephanie
    Ramarao, Nalini
    MSYSTEMS, 2021, 6 (05)
  • [23] A critical review on the impacts of β-glucans on gut microbiota and human health
    Jayachandran, Muthukumaran
    Chen, Jiali
    Chung, Stephen Sum Man
    Xu, Baojun
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2018, 61 : 101 - 110
  • [24] Head Hair Total Mercury and Methylmercury Levels in Some Ghanaian Individuals for the Estimation of Their Exposure to Mercury: Preliminary Studies
    Ray B. Voegborlo
    Akito Matsuyama
    Anthony A. Adimado
    Hirokatsu Akagi
    Bulletin of Environmental Contamination and Toxicology, 2010, 84 : 34 - 38
  • [25] Head Hair Total Mercury and Methylmercury Levels in Some Ghanaian Individuals for the Estimation of Their Exposure to Mercury: Preliminary Studies
    Voegborlo, Ray B.
    Matsuyama, Akito
    Adimado, Anthony A.
    Akagi, Hirokatsu
    BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2010, 84 (01) : 34 - 38
  • [26] Mercury Isotope Study of Sources and Exposure Pathways of Methylmercury in Estuarine Food Webs in the Northeastern US
    Kwon, Sae Yun
    Blum, Joel D.
    Chen, Celia Y.
    Meattey, Dustin E.
    Mason, Robert P.
    ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2014, 48 (17) : 10089 - 10097
  • [27] Impacts of Penconazole and Its Enantiomers Exposure on Gut Microbiota and Metabolic Profiles in Mice
    Meng, Zhiyuan
    Liu, Li
    Jia, Ming
    Li, Ruisheng
    Yan, Sen
    Tian, Sinuo
    Sun, Wei
    Zhou, Zhiqiang
    Zhu, Wentao
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (30) : 8303 - 8311
  • [28] Dietary pattern interfered with the impacts of pesticide exposure by regulating the bioavailability and gut microbiota
    Chen, Ai Song
    Liu, Dong Hui
    Hou, Hao Nan
    Yao, Jia Ning
    Xiao, Shou Chun
    Ma, Xiao Ran
    Li, Pei Ze
    Cao, Qian
    Liu, Xue Ke
    Zhou, Zhi Qiang
    Wang, Peng
    SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 858
  • [29] Exposure to prescribed medication in early life and impacts on gut microbiota and disease development
    Huang, Huan
    Jiang, Jiayin
    Wang, Xinyu
    Jiang, Kui
    Cao, Hailong
    ECLINICALMEDICINE, 2024, 68
  • [30] Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure
    Perez, Laeticia
    Scarcello, Eleonora
    Ibouraadaten, Saloua
    Yakoub, Yousof
    Leinardi, Riccardo
    Ambroise, Jerome
    Bearzatto, Bertrand
    Gala, Jean-Luc
    Paquot, Adrien
    Muccioli, Giulio G.
    Bouzin, Caroline
    van den Brule, Sybille
    Lison, Dominique
    FOOD AND CHEMICAL TOXICOLOGY, 2021, 154