Zyzzyanone A, a novel pyrrolo[3,2-f]indole alkaloid from the Australian marine sponge Zyzzya fuliginosa

被引：26

作者：

Utkina, NK ^{[1
]}

Makarchenko, AE

Denisenko, VA

Dmitrenok, PS

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

[2] Far Eastern State Univ, Dept Bioorgan Chem & Biotechnol, Vladivostok 690600, Russia

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 40期

基金：

俄罗斯基础研究基金会;

关键词：

sponges; dipyrroloquinones; pyrrolo[3,2-f]indole; pyrrolo[4,3,2-de]quinoline; alkaloids;

D O I：

10.1016/j.tetlet.2004.08.057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new dipyrroloquinone, zyzzyanone A 1, having a pyrrolo[3,2 f]indole-4,8(1H,7H)-dione skeleton, was isolated from the Australian marine sponge Zyzzya fuliginosa, along with the known pyrroloquinoline alkaloids, makaluvamines C, E, G, H, and L, and damirones A and B. The structure of 1 was determined by spectroscopic data. Zyzzyanone A 1 shows moderate cytotoxic activity against mouse Ehrlich carcinoma cells (IC50 25 mug/mL), inhibits the cell division of fertilized sea urchin eggs at a concentration of 25 mug/mL, and exhibits UV-A and UV-B absorbing activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7491 / 7494

页数：4

共 23 条

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