Haem-oxygen reactive intermediates: catalysis by the two-step

被引：8

作者：

Makris, TM

Denisov, IG

Sligar, SG ^{[1
]}

机构：

[1] Univ Illinois, Dept Biochem, 505 S Goodwin Ave, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[3] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA

[4] Univ Illinois, Coll Med, Urbana, IL 61801 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷

关键词：

dioxygen activation; P450; mechanism;

D O I：

10.1042/BST0310516

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The catalytic schemes of a variety of haem enzymes, including the P450 mono-oxygenases, consist of a number of common reactive haem-oxygen adducts. The characterization of these intermediates by optical and EPR spectroscopies has reinforced the similarity of these intermediate states in a number of haem enzyme systems. Furthermore, the reactivity of these states in P450 and horseradish peroxidase, in which multiple potent oxidants are formed, provides a paradigm for many other haem enzymes.

引用

页码：516 / 519

页数：4

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