Two new cytotoxic steroids from the Chinese soft coral Sinularia sp.

被引：25
|
作者：
Li, Song-Wei [1 ,2 ]
Chen, Wen-Ting [2 ]
Yao, Li-Gong [2 ]
Guo, Yue-Wei [2 ]
机构：
[1] Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangiiang Hitech Pk, Shanghai 201203, Peoples R China
来源：
STEROIDS | 2018年 / 136卷
关键词：
Sinularia; Polyhydroxylated steroids; Modified Mosher's method; Cytotoxicity; POLYOXYGENATED STEROIDS; PHARMACOLOGICAL-ACTIVITIES; POLYHYDROXYLATED STEROIDS;
D O I：
10.1016/j.steroids.2018.05.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new steroids, ximaosteroid E (1) and ximaosteroid F (2), along with two known related compounds (3 and 4), were isolated from the Chinese soft coral Sinularia sp. Notably, 1 possesses an uncommon dihydrofuran group. Their structures were established from extensive spectroscopic analyses and comparisons of their spectral data with those reported in the literature. The absolute configuration of 2 was determined by applying the modified Mosher's method. In bioassay, compounds 1, 2, and 4 showed significant cytotoxicity against the HL-60 tumor cell line with IC50 values of 1.79, 4.03 and 0.69 mu M, respectively.
引用
收藏
页码：17 / 21
页数：5
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