Synovium Derived Mesenchymal Stromal Cells (Sy-MSCs): A Promising Therapeutic Paradigm in the Management of Knee Osteoarthritis

被引：7
|
作者：
Jeyaraman, Madhan [1 ,2 ,3 ]
Muthu, Sathish [2 ,3 ,4 ]
Jeyaraman, Naveen [3 ,5 ]
Ranjan, Rajni [1 ]
Jha, Saurabh Kumar [2 ,3 ]
Mishra, Prabhu [3 ]
机构：
[1] Sharda Univ, Sch Med Sci & Res, Dept Orthopaed, Greater Noida, Uttar Pradesh, India
[2] Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida, Uttar Pradesh, India
[3] Int Assoc Stemcell & Regenerat Med IASRM, New Delhi, India
[4] Govt Med Coll Sr Hosp, Dept Orthopaed, Dindigul, Tamil Nadu, India
[5] MAHE Univ, Kasturba Med Coll, Dept Orthopaed, Manipal, Karnataka, India
来源：
INDIAN JOURNAL OF ORTHOPAEDICS | 2022年 / 56卷 / 01期
关键词：
Synovium; Mesenchymal stromal cell; Chondrogenicity; Osteoarthritis knee; INFRAPATELLAR FAT PAD; STEM-CELLS; ADIPOSE-TISSUE; BONE-MARROW; CHONDROGENIC DIFFERENTIATION; EXTRACELLULAR-MATRIX; CARTILAGE DEFECTS; PROGENITOR CELLS; REPAIR; MEMBRANE;
D O I：
10.1007/s43465-021-00439-w
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Synovium-derived mesenchymal stromal cell (Sy-MSC) is a newer member of the mesenchymal stromal cell families. The first successful demonstration of the mesenchymal stromal cell from the human synovial membrane was done in 2001 and since then its potential role for musculoskeletal regeneration has been keenly documented. The regenerative effects of Sy-MSCs are through paracrine signaling, direct cell-cell interactions, and extracellular vehicles. Sy-MSCs possess superior chondrogenicity than other sources of mesenchymal stromal cells. This article aims to outline the advancement of synovium-derived mesenchymal stromal cells along with a specific insight into the application for managing osteoarthritis knee.
引用
收藏
页码：1 / 15
页数：15
相关论文
共 50 条
  • [41] Exosomes derived from mesenchymal stromal cells: a promising treatment for pelvic floor dysfunction
    Xu, Leimei
    Sima, Yizhen
    Xiao, Chengzhen
    Chen, Yisong
    HUMAN CELL, 2023, 36 (03) : 937 - 949
  • [42] Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis
    Luo, Danni
    Zhu, Hao
    Li, Song
    Wang, Zhenggang
    Xiao, Jun
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2024, 12
  • [43] Exosomes derived from mesenchymal stromal cells: a promising treatment for pelvic floor dysfunction
    Leimei Xu
    Yizhen Sima
    Chengzhen Xiao
    Yisong Chen
    Human Cell, 2023, 36 : 937 - 949
  • [44] Umbilical cord-derived mesenchymal stromal cells: Promising therapy for heart failure
    Li, Ya-Lun
    Chen, En-Guo
    Ren, Bing-Bing
    WORLD JOURNAL OF CARDIOLOGY, 2025, 17 (01):
  • [45] Characterization of Mesenchymal Stromal Cells (MSCs) Derived From Acute Myeloid Leukemia (AML) Bone Marrow
    Basu, Soumit K.
    Zhao, Xin
    Chien, Sylvia
    Fang, Min
    Oehler, Vivian
    Becker, Pamela S.
    BLOOD, 2011, 118 (21) : 1097 - 1097
  • [46] Effect of Aerobic and Resistance Exercise Training on Fat Derived Mesenchymal Stromal Cells (MSCs) in Subjects with Prediabetes
    Kundu, Nabanita
    Domingues, Cleyton
    Paal, Edina
    Kokkinos, Peter
    Nylen, Eric
    Sen, Sabyasachi
    MOLECULAR THERAPY, 2017, 25 (05) : 115 - 115
  • [47] Mesenchymal stromal cells (MSCs) as a therapeutic agent of inflammatory disease and infectious COVID-19 virus: live or dead mesenchymal?
    Kheder, Ramiar Kamal
    Darweesh, Omeed
    Hussen, Bashdar Mahmud
    Abdullah, Snur Rasool
    Basiri, Abbas
    Taheri, Mohammad
    MOLECULAR BIOLOGY REPORTS, 2024, 51 (01)
  • [48] Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
    Matas, Jose
    Orrego, Mario
    Amenabar, Diego
    Infante, Catalina
    Tapia-Limonchi, Rafael
    Ignacia Cadiz, Maria
    Alcayaga-Miranda, Francisca
    Gonzalez, Paz L.
    Muse, Emilio
    Khoury, Maroun
    Figueroa, Fernando E.
    Espinoza, Francisco
    STEM CELLS TRANSLATIONAL MEDICINE, 2019, 8 (03) : 215 - 224
  • [49] INFLUENCE OF ADIPOKINES ON DIFFERENTIATION OF OSTEOARTHRITIS AND OSTEOPOROSIS SPONGIOSA-DERIVED MESENCHYMAL STROMAL CELLS
    Tsiklauri, Lali
    Werner, Janina
    Frommer, Klaus W.
    Engel, Rosel
    Rehat, Stefan
    Wenisch, Sabine
    Mueller-Ladner, Ulf
    Neumann, Elena
    ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 : A41 - A42
  • [50] Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization
    Ferrer-Lorente, R.
    Sanjurjo-Rodriguez, C.
    Richaud-Patin, Y.
    Blanco, F. J.
    Badimon, L.
    Raya, A.
    CARDIOVASCULAR RESEARCH, 2016, 111 : S57 - S57
12345