DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells

被引：665
|
作者：
Tassaneetrithep, B
Burgess, TH
Granelli-Piperno, A
Trumpfherer, C
Finke, J
Sun, W
Eller, MA
Pattanapanyasat, K
Sarasombath, S
Birx, DL
Steinman, RM
Schlesinger, S
Marovich, MA
机构：
[1] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA
[2] Henry M Jackson Fdn Adv Mil Med Dis, Rockville, MD 20850 USA
[3] Naval Med Res Ctr, Dept Virus Dis, Bethesda, MD 20889 USA
[4] Rockefeller Univ, Cellular Physiol & Immunol Lab, New York, NY 10021 USA
[5] Walter Reed Army Inst Res, Dept Virus Dis, Bethesda, MD 20889 USA
[6] Mahidol Univ, Div Instruments Res, Med Siriraj Hosp, Bangkok 10700, Thailand
[7] Mahidol Univ, Dept Immunol, Med Siriraj Hosp, Bangkok 10700, Thailand
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2003年 / 197卷 / 07期
关键词：
receptor; flavivirus; lectin; antigen-presenting cells; virus receptor;
D O I：
10.1084/jem.20021840
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti-DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infections for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection.
引用
收藏
页码：823 / 829
页数：7
相关论文
共 50 条
  • [41] DC-SIGN (CD209) Promoter-336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease
    Yu, Hong-Ren
    Chang, Wei-Pin
    Wang, Lin
    Lin, Ying-Jui
    Liang, Chi-Di
    Yang, Kuender D.
    Kuo, Chiu-Ming
    Huang, Yi-Chuan
    Chang, Wei-Chiao
    Kuo, Ho-Chang
    SCIENTIFIC WORLD JOURNAL, 2012,
  • [42] Differential Gene Expression Profiles of Human Monocyte-Derived Antigen Presenting Cells in Response to Penicillium marneffei: Roles of DC-SIGN (CD209) in Fungal Cell Uptake
    Ngaosuwankul, Piyaporn
    Pongtanalert, Piyapong
    Engering, Aneke
    Chaiyaroj, Sansanee C.
    ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 2008, 26 (2-3): : 151 - 163
  • [43] DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans
    R Olesen
    C Wejse
    D R Velez
    C Bisseye
    M Sodemann
    P Aaby
    P Rabna
    A Worwui
    H Chapman
    M Diatta
    R A Adegbola
    P C Hill
    L Østergaard
    S M Williams
    G Sirugo
    Genes & Immunity, 2007, 8 : 456 - 467
  • [44] DC-SIGN: A guide to some mysteries of dendritic cells
    Steinman, RM
    CELL, 2000, 100 (05) : 491 - 494
  • [45] Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection
    Alen, Marijke M. F.
    Kaptein, Suzanne J. F.
    De Burghgraeve, Tine
    Balzarini, Jan
    Neyts, Johan
    Schols, Dominique
    VIROLOGY, 2009, 387 (01) : 67 - 75
  • [46] Isolation and propagation of Dengue virus in Vero and BHK-21 cells expressing human DC-SIGN stably
    Phanthanawiboon, Supranee
    A-nuegoonpipat, Atchareeya
    Panngarm, Narawan
    Limkittikul, Kriengsak
    Ikuta, Kazuyoshi
    Anabtapreecha, Surapee
    Kurosu, Takeshi
    JOURNAL OF VIROLOGICAL METHODS, 2014, 209 : 55 - 61
  • [47] DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans
    Olesen, R.
    Wejse, C.
    Velez, D. R.
    Bisseye, C.
    Sodemann, M.
    Aaby, P.
    Rabna, P.
    Worwui, A.
    Chapman, H.
    Diatta, M.
    Adegbola, Ra
    Hill, Pc
    Ostergaard, L.
    Williams, S. M.
    Sirugo, G.
    GENES AND IMMUNITY, 2007, 8 (06) : 456 - 467
  • [48] CD209 (DC-SIGN)-336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese
    Chan, Kelvin Yuen Kwong
    Xu, Mei-Shu
    Ching, Johannes Chi Yun
    So, Thomas Man Kit
    Lai, Sik-To
    Chu, Chung-Ming
    Yam, Loretta Y. C.
    Wong, Andrew T. Y.
    Chung, Pui Hong
    Chan, Vera Sau Fong
    Lin, Chen Lung Steve
    Sham, Pak Chung
    Leung, Gabriel M.
    Peiris, Joseph S. M.
    Khoo, Ui-Soon
    HUMAN IMMUNOLOGY, 2010, 71 (07) : 702 - 707
  • [49] Association of promoter region polymorphisms of CD209 gene with clinical outcomes of dengue virus infection in Western India
    Alagarasu, Kalichamy
    Damle, Indraneel M.
    Bachal, Rupali V.
    Mulay, Aditya P.
    Shah, Paresh S.
    Dayaraj, Cecilia
    INFECTION GENETICS AND EVOLUTION, 2013, 17 : 239 - 242
  • [50] Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes
    Colmenares, M
    Puig-Kröger, A
    Pello, OM
    Corbí, AL
    Rivas, L
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (39) : 36766 - 36769
12345