A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors (vol 20, pg 153, 2010)

被引:0
|
作者
Wang, Tiansheng [1 ]
Ledeboer, Mark W. [1 ]
Duffy, John P. [1 ]
Salituro, Francesco G. [1 ]
Pierce, Albert C. [1 ]
Zuccola, Harmon J. [1 ]
Block, Eric [1 ]
Shlyakter, Dina [1 ]
Hogan, James K. [1 ]
Bennani, Youssef L. [1 ]
机构
[1] Vertex Pharmaceut Inc, Cambridge, MA 02139 USA
关键词
D O I
10.1016/j.bmcl.2010.02.078
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:2684 / 2684
页数:1
相关论文
共 15 条
  • [11] Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors (vol 20, pg 1924, 2010)
    Hanessian, Stephen
    Shao, Zhihui
    Betschart, Claudia
    Rondeau, Jean-Michel
    Neumann, Ulf
    Tintelnot-Blomley, Marina
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (08) : 2460 - 2461
  • [12] Benzo[c][2,7]naphthyridin-5(6H)-one and 5H-chromeno[3,4-c]pyridine as potent inhibitors of a novel serine/threonine kinase for the potential treatment of neuropathic
    Dzierba, Carolyn
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [13] Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer
    William, Anthony D.
    Lee, Angeline C. -H.
    Goh, Kee Chuan
    Blanchard, Stephanie
    Poulsen, Anders
    Teo, Ee Ling
    Nagaraj, Harish
    Lee, Chai Ping
    Wang, Haishan
    Williams, Meredith
    Sun, Eric T.
    Hu, Changyong
    Jayaraman, Ramesh
    Pasha, Mohammed Khalid
    Ethirajulu, Kantharaj
    Wood, Jeanette M.
    Dymock, Brian W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (01) : 169 - 196
  • [14] Discovery of the Macrocycle (9E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,-4,9,14(26),15,17,20,22-nonaene (SB1578), a Potent Inhibitor of Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) for the Treatment of Rheumatoid Arthritis
    William, Anthony D.
    Lee, Angeline C. -H.
    Poulsen, Anders
    Goh, Kee Chuan
    Madan, Babita
    Hart, Stefan
    Tan, Evelyn
    Wang, Haishan
    Nagaraj, Harish
    Chen, Dizhong
    Lee, Chai Ping
    Sun, Eric T.
    Jayaraman, Ramesh
    Pasha, Mohammad Khalid
    Ethirajulu, Kantharaj
    Wood, Jeanette M.
    Dymock, Brian W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (06) : 2623 - 2640
  • [15] Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer (vol 55, pg 8091, 2012)
    Cui, J. Jean
    McTigue, Michele
    Nambu, Mitchell
    Tran-Dube, Michelle
    Pairish, Mason
    Shen, Hong
    Jia, Lei
    Cheng, Hengmiao
    Hoffman, Jacqui
    Le, Phuong
    Jalaie, Mehran
    Goetz, Gilles H.
    Koenig, Marcel
    Vojkovsky, Tomas
    Zhang, Fang-Jie
    Do, Steven
    Botrous, Iriny
    Ryan, Kevin
    Grodsky, Neil
    Deng, Ya-li
    Parker, Max
    Timofeevski, Sergei
    Murray, Brion W.
    Yamazaki, Shinji
    Aguirre, Shirley
    Li, Qiuhua
    Zou, Helen
    Christensen, James
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (22) : 10314 - 10314