Inhibition of PI3K leads to a block in TPO-induced cell cycling at G1/s in both BaF3/Mpl cells and in primary megakaryocytic progenitors.

被引：0
|
作者：
Geddis, AE [1 ]
Fox, NE [1 ]
Kaushansky, K [1 ]
机构：
[1] Univ Washington, Seattle, WA 98195 USA
来源：
BLOOD | 2000年 / 96卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2318
引用
收藏
页码：539A / 539A
页数：1
相关论文
共 41 条
  • [21] Intact regulation of G1/S transition renders esophageal squamous cell carcinomas sensitive to PI3Kα inhibitors by blocking SKP2-mediated p21 degradation
    Wang, Yuxiang
    Zhang, Xu
    Zhang, Xi
    Shen, Yanyan
    Ma, Qingyang
    Qiao, Yuemei
    Wang, Yi
    Yang, Biyu
    Xu, Lan
    Ge, Gaoxiang
    Hu, Landian
    Kong, Xiangyin
    Yang, Chunhao
    Ding, Jian
    Chen, Yi
    Meng, Linghua
    CANCER RESEARCH, 2022, 82 (12)
  • [22] Tetrachlorobisphenol A and bisphenol AF induced cell migration by activating PI3K/Akt signaling pathway via G protein-coupled estrogen receptor 1 in SK-BR-3 cells
    Yu, Mengjie
    Xu, Lanbing
    Lei, Bingli
    Sun, Su
    Yang, Yingxin
    ENVIRONMENTAL TOXICOLOGY, 2023, 38 (01) : 126 - 135
  • [23] Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway
    Ran Wang
    Qian Zhang
    Xin Peng
    Chang Zhou
    Yuxu Zhong
    Xi Chen
    Yuling Qiu
    Meihua Jin
    Min Gong
    Dexin Kong
    Scientific Reports, 6
  • [24] Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway
    Wang, Ran
    Zhang, Qian
    Peng, Xin
    Zhou, Chang
    Zhong, Yuxu
    Chen, Xi
    Qiu, Yuling
    Jin, Meihua
    Gong, Min
    Kong, Dexin
    SCIENTIFIC REPORTS, 2016, 6
  • [25] Network pharmacology and in vitro experiments reveal sophoridine-induced apoptosis and G1 phase arrest via ROS-dependent PI3K/Akt/FoxO3a pathway activation in human bladder cancer cells
    Su, Yao
    Chen, Lin
    Yang, Jin
    CHEMICAL BIOLOGY & DRUG DESIGN, 2024, 103 (02)
  • [26] Asparanin A from Asparagus officinalis L. Induces G0/G1 Cell Cycle Arrest and Apoptosis in Human Endometrial Carcinoma Ishikawa Cells via Mitochondrial and PI3K/AKT Signaling Pathways
    Zhang, Fan
    Zhang, Yuan-Yuan
    Sun, Ya-Sai
    Ma, Run-Hui
    Thakur, Kiran
    Zhang, Jian-Guo
    Wei, Zhao-Jun
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 68 (01) : 213 - 224
  • [27] Antiproliferative and Pro-Apoptotic Effect of Uvaol in Human Hepatocarcinoma HepG2 Cells by Affecting G0/G1 Cell Cycle Arrest, ROS Production and AKT/PI3K Signaling Pathway
    Bonel-Perez, Gloria C.
    Perez-Jimenez, Amalia
    Gris-Cardenas, Isabel
    Parra-Perez, Alberto M.
    Lupianez, Jose Antonio
    Reyes-Zurita, Fernando J.
    Siles, Eva
    Csuk, Rene
    Peragon, Juan
    Rufino-Palomares, Eva E.
    MOLECULES, 2020, 25 (18):
  • [28] Latcripin-7A from Lentinula edodes C91-3 induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling
    Din, Syed Riaz Ud
    Nisar, Muhammad Azhar
    Ramzan, Muhammad Noman
    Saleem, Muhammad Zubair
    Ghayas, Hassan
    Ahmad, Bashir
    Batool, Samana
    Kifayat, Kashif
    Guo, Xiaorong
    Huang, Min
    Zhong, Mintao
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 907
  • [29] CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells
    Hoang, Anh Thu Nguyen
    Hoe, Kwang-Lae
    Lee, Sook-Jeong
    PLOS ONE, 2021, 16 (04):
  • [30] Effects of MEK1 and PI3K inhibitors on allyl-, benzyl- and phenylethyl-isothiocyanate-induced G2/M arrest and cell death in Caco-2 cells
    Jakubíková, J
    Sedlák, A
    Bacon, J
    Goldson, A
    Bao, YP
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2005, 27 (05) : 1449 - 1458
12345