Dioxygen activation of iron bleomycin and the cleavage of DNA

被引：3
|
作者：
Peisach, J [1 ]
机构：
[1] Albert Einstein Coll Med, Dept Physiol & Biophys, Bronx, NY 10461 USA
来源：
OXYGEN AND LIFE: OXYGENASES, OXIDASE AND LIPID MEDIATORS | 2002年 / 1233卷
关键词：
bleomycin; oxygen activation; DNA cleavage;
D O I：
10.1016/S0531-5131(02)00270-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The anticancer drug bleomycin cleaves DNA in a reaction requiring Fe2+ and O-2 or Fe3+ and H2O2. The activation of the Fe drug complex resembles that seen for cytochrome P-450. Unlike P-450, bleomycin functions as an oxidase rather than an oxygenase. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：511 / 517
页数：7
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