Nerve growth factor (NGF) and NGF mRNA change in rat uterus during pregnancy

被引：40
|
作者：
Varol, FG
Duchemin, AM
Neff, NH
Hadjiconstantinou, M [1 ]
机构：
[1] Ohio State Univ, Coll Med & Publ Hlth, Dept Psychiat, Columbus, OH 43210 USA
[2] Trakya Univ, Dept Obstet & Gynecol, Edirine, Turkey
[3] Ohio State Univ, Coll Med & Publ Hlth, Dept Pharmacol, Columbus, OH 43210 USA
来源：
NEUROSCIENCE LETTERS | 2000年 / 294卷 / 01期
关键词：
nerve growth factor; nerve growth factor mRNA; uterus; pregnancy; sympathetic neurons; denervation;
D O I：
10.1016/S0304-3940(00)01533-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
During pregnancy, the uterus undergoes a profound sympathetic denervation. To explore whether this is associated with changes in neurotrophic factors, we assayed nerve growth factor (NGF) and NGF mRNA in the uterus of non-pregnant and pregnant rats. In the uterine horn, the concentration of NGF and its mRNA decreased during middle and late pregnancy. However, when values were corrected for the increase of uterine weight and total RNA yield during pregnancy, NGF content and mRNA per horn increased during middle and late pregnancy. Similar, but less pronounced, changes were observed in the cervix. By seven days postpartum, both parameters returned to near normal. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：58 / 62
页数：5
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