Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

被引：126

作者：

Zhuang, Wei-Zhan ^{[1
,2
,3
]}

Lin, Yi-Heng ^{[1
,4
,5
]}

Su, Long-Jyun ^{[6
]}

Wu, Meng-Shiue ^{[7
]}

Jeng, Han-Yin ^{[1
,3
]}

Chang, Huan-Cheng ^{[6
,8
]}

Huang, Yen-Hua ^{[1
,2
,3
,9
,10
,11
,12
]}

Ling, Thai-Yen ^{[7
,13
]}

机构：

[1] Taipei Med Univ, Coll Med, Sch Med, Dept Biochem & Mol Cell Biol, 250 Wuxing St, Taipei 11031, Taiwan

[2] Taipei Med Univ, Coll Med, Grad Inst Med Sci, 250 Wuxing St, Taipei 11031, Taiwan

[3] Taipei Med Univ, TMU Res Ctr Cell Therapy & Regenerat Med, 250 Wuxing St, Taipei 11031, Taiwan

[4] Natl Taiwan Univ, Coll Med, Dept Obstet & Gynecol, Taipei 10041, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, Yunlin Branch, Taipei 64041, Taiwan

[6] Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

[7] Natl Taiwan Univ, Coll Med, Dept & Grad Inst Pharmacol, Taipei 10617, Taiwan

[8] Natl Taiwan Univ Sci & Technol, Dept Chem Engn, Taipei 106, Taiwan

[9] Taipei Med Univ, Coll Med, Int PhD Program Cell Therapy & Regenerat Med, Taipei 11031, Taiwan

[10] Taipei Med Univ, Taipei Med Univ Hosp, Ctr Reprod Med, Taipei 11031, Taiwan

[11] Taipei Med Univ, Comprehens Canc Ctr, Taipei 11031, Taiwan

[12] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Translat Med, Taipei 11031, Taiwan

[13] Natl Taiwan Univ, Res Ctr Dev Biol & Regenerat Med, Taipei 100, Taiwan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2021年 / 28卷 / 01期

关键词：

Mesenchymal stem; stromal cell; Cell therapy; Systemic safety; biodistribution; Single cell imaging;

D O I：

10.1186/s12929-021-00725-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy because of their high immunomodulation ability, tropism towards inflamed and injured tissues, and their easy access and isolation. Currently, there are more than 1200 registered MSC clinical trials globally. However, a lack of standardized methods to characterize cell safety, efficacy, and biodistribution dramatically hinders the progress of MSC utility in clinical practice. In this review, we summarize the current state of MSC-based cell therapy, focusing on the systemic safety and biodistribution of MSCs. MSC-associated risks of tumor initiation and promotion and the underlying mechanisms of these risks are discussed. In addition, MSC biodistribution methodology and the pharmacokinetics and pharmacodynamics of cell therapies are addressed. Better understanding of the systemic safety and biodistribution of MSCs will facilitate future clinical applications of precision medicine using stem cells.

引用

页数：38

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