Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer

被引：6
|
作者：
Yu, W. H. [1 ]
Wang, Y. X. [1 ]
Guo, J. Q. [1 ]
Wang, Y. L. [2 ]
Zheng, J. S. [3 ]
Zhu, K. X. [1 ]
机构：
[1] Shandong Univ, Dept Gastroenterol, Hosp 2, Jinan 250100, Peoples R China
[2] Shandong Univ, Dept Pediat, Hosp 2, Jinan 250100, Peoples R China
[3] Shandong Canc Hosp & Inst, Dept Radiol, Jinan, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 04期
关键词：
ERCC1; ERCC2; Polymorphism; Gastric cancer; Clinical outcome; DNA-REPAIR; POLYMORPHISMS; CHEMOTHERAPY; PROGNOSIS; MECHANISM;
D O I：
10.4238/2015.December.21.25
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARRAY platform. The GA+AA genotype of ERCC2 rs1799793 showed significant and favorable response to chemotherapy than the wide-type GG genotype in multivariate analysis (OR = 1.78, 95% CI = 1.13-2.81). In a Cox proportional hazard model, carriers of ERCC2 rs1799793 GA+AA genotype exhibited longer duration of survival than did those with the GG genotype (hazards ratio = 0.57, 95% CI = 0.35-0.92). In conclusion, our study suggests that ERCC2 rs1799793 polymorphic variation could be used as a predictor for the prognosis of gastric cancer.
引用
收藏
页码：17529 / 17535
页数：7
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