The sleep-deprived human brain

被引：649
|
作者：
Krause, Adam J. [1 ]
Ben Simon, Eti [1 ]
Mander, Bryce A. [1 ]
Greer, Stephanie M. [2 ]
Saletin, Jared M. [1 ]
Goldstein-Piekarski, Andrea N. [2 ]
Walker, Matthew P. [1 ,2 ]
机构：
[1] Univ Calif Berkeley, Dept Psychol, 3210 Tolman Hall, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
来源：
NATURE REVIEWS NEUROSCIENCE | 2017年 / 18卷 / 07期
基金：
美国国家卫生研究院;
关键词：
POSTTRAUMATIC-STRESS-DISORDER; DEFAULT MODE NETWORK; WORKING-MEMORY; FUNCTIONAL CONNECTIVITY; DEPRIVATION IMPAIRS; REM-SLEEP; ACETYLCHOLINE-RELEASE; RESTED WAKEFULNESS; PREFRONTAL CORTEX; TRAUMA NIGHTMARES;
D O I：
10.1038/nrn.2017.55
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
How does a lack of sleep affect our brains? In contrast to the benefits of sleep, frameworks exploring the impact of sleep loss are relatively lacking. Importantly, the effects of sleep deprivation (SD) do not simply reflect the absence of sleep and the benefits attributed to it; rather, they reflect the consequences of several additional factors, including extended wakefulness. With a focus on neuroimaging studies, we review the consequences of SD on attention and working memory, positive and negative emotion, and hippocampal learning. We explore how this evidence informs our mechanistic understanding of the known changes in cognition and emotion associated with SD, and the insights it provides regarding clinical conditions associated with sleep disruption.
引用
收藏
页码：404 / 418
页数：15
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