A New Bioactive Metabolite Isolated from the Red Sea Marine Sponge Hyrtios erectus

被引：26
|
作者：
Elhady, Sameh S. [1 ,2 ]
El-Halawany, Ali M. [2 ,3 ]
Alahdal, Abdulrahman M. [4 ]
Hassanean, Hashim A. [1 ]
Ahmed, Safwat A. [1 ]
机构：
[1] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt
[2] King Abdulaziz Univ, Dept Nat Prod & Alternat Med, Fac Pharm, Jeddah 21589, Saudi Arabia
[3] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Kasr el Aini St, Cairo 11562, Egypt
[4] King Abdulaziz Univ, Fac Pharm, Dept Clin Pharm, Jeddah 21589, Saudi Arabia
来源：
MOLECULES | 2016年 / 21卷 / 01期
关键词：
Red Sea sponge; Hyrtios erectus; 24-methoxypetrosaspongia C; scalarane sesterterpenes; cancer cell lines; growth inhibitory activity; SCALARIN-LIKE PYRROLOTERPENE; ANTINEOPLASTIC AGENTS; CACOSPONGIA-MOLLIOR; NATURAL-PRODUCTS; ALTOHYRTIN-A; CELL-LINES; SESTERTERPENES; FOLIASCENS; ALKALOIDS; MACROLIDE;
D O I：
10.3390/molecules21010082
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemical investigation of the lipophilic fraction of Hyrtios erectus, a Red Sea sponge, yielded a new pentacyclic nitrogen-containing scalarane; 24-methoxypetrosaspongia C (1), together with the previously reported scalaranes sesterstatin 3 (2), 12-deacetyl-12-epi-scalaradial (3) and 12-deacetyl-12,18-di-epi-scalaradial (4). The compounds were identified using HRESIMS, 1D and 2D NMR experiments. The isolated compounds showed growth inhibitory activity against hepatocellular carcinoma (HepG2), colorectal carcinoma (HCT-116) and breast adenocarcinoma cells (MCF-7).
引用
收藏
页数：9
相关论文
共 50 条
  • [31] Sesterterpenes and phenolic alkenes from the Thai sponge Hyrtios erectus
    Kaweetripob, Wirongrong
    Mahidol, Chulabhorn
    Wongbundit, Siriporn
    Tuntiwachwuttikul, Pittaya
    Ruchirawat, Somsak
    Prawat, Hunsa
    TETRAHEDRON, 2018, 74 (02) : 316 - 323
  • [32] Dipuupehedione, a Cytotoxic New Red Dimer from a New Caledonian Marine Sponge Hyrtios sp.
    Tetrahedron Lett, 22 (3861):
  • [33] Bioactive Hydantoin Alkaloids from the Red Sea Marine Sponge Hemimycale arabica
    Youssef, Diaa T. A.
    Shaala, Lamiaa A.
    Alshali, Khalid Z.
    MARINE DRUGS, 2015, 13 (11): : 6609 - 6619
  • [34] Bioactive alkaloids from the Red Sea marine Verongid sponge Pseudoceratina arabica
    Shaala, Lamiaa A.
    Youssef, Diaa T. A.
    Badr, Jihan M.
    Sulaiman, Mansour
    Khedr, Alaa
    El Sayed, Khalid A.
    TETRAHEDRON, 2015, 71 (41) : 7837 - 7841
  • [35] Network Pharmacological Analysis of the Red Sea Sponge Hyrtios erectus Extract to Reveal Anticancer Efficacy of Corresponding Loaded Niosomes
    Abou-Taleb, Heba A.
    Sayed, Ahmed M.
    Refaat, Hesham
    Alsenani, Faisal
    Alaaeldin, Eman
    Mokhtar, Fatma A.
    Abdelmohsen, Usama Ramadan
    Shady, Nourhan Hisham
    MARINE DRUGS, 2022, 20 (10)
  • [36] Salmahyrtisol A, a novel cytotoxic sesterterpene from the Red Sea sponge Hyrtios erecta
    Youssef, DTA
    Yamaki, RK
    Kelly, M
    Scheuer, PJ
    JOURNAL OF NATURAL PRODUCTS, 2002, 65 (01): : 2 - 6
  • [37] Hyrtiosenolides A and B, two new sesquiterpene γ-methoxybutenolides and a new sterol from a Red Sea sponge Hyrtios species
    Youssef, DTA
    Singab, ANB
    van Soest, RWM
    Fusetani, N
    JOURNAL OF NATURAL PRODUCTS, 2004, 67 (10): : 1736 - 1739
  • [38] Bioactive Scalaranes from the Thai Sponge Hyrtios gumminae
    Mahidol, Chulabhorn
    Prawat, Hunsa
    Sangpetsiripan, Suwannee
    Ruchirawat, Somsak
    JOURNAL OF NATURAL PRODUCTS, 2009, 72 (10): : 1870 - 1874
  • [39] Bioactive Secondary Metabolites from the Red Sea Marine Verongid Sponge Suberea Species
    Shaala, Lamiaa A.
    Youssef, Diaa T. A.
    Badr, Jihan M.
    Sulaiman, Mansour
    Khedr, Alaa
    MARINE DRUGS, 2015, 13 (04): : 1621 - 1631
  • [40] New compounds from the Red Sea marine sponge Echinoclathria gibbosa
    Mohamed, Gamal A.
    Abd-Elrazek, Ali E. E.
    Hassanean, Hashim A.
    Youssef, Diaa T. A.
    van Soest, Rob
    PHYTOCHEMISTRY LETTERS, 2014, 9 : 51 - 58
12345