Circulating tumour-derived predictive biomarkers in oncology

被引：17

作者：

Hodgson, Darren R. ^{[1
]}

Wiellings, Robert ^{[1
]}

Orr, Maria C. M. ^{[1
]}

McCormack, Rose ^{[1
]}

Malone, Michael ^{[1
]}

Board, Ruth E. ^{[2
]}

Cantarini, Mireille V. ^{[1
]}

机构：

[1] AstraZeneca, Oncol Therapy Area, Macclesfield SK10 4TG, Cheshire, England

[2] Christie Hosp, Dept Med Oncol, Manchester M20 4BX, Lancs, England

来源：

DRUG DISCOVERY TODAY | 2010年 / 15卷 / 3-4期

关键词：

CANCER-PATIENTS; BREAST-CANCER; PLASMA DNA; MUTATIONS; CELLS; GEFITINIB; MARKERS; SERUM; EGFR; EXPRESSION;

D O I：

10.1016/j.drudis.2009.12.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Molecular characterization of tumour material will become increasingly important in selecting patients for clinical trials and offering appropriate treatment for patients in clinical practice. Recent advances in the field have indicated that the molecular characteristics of a tumour can be determined from circulating tumour cells and circulating tumour DNA; thus, a simple blood sample could provide these data in a simple, convenient and efficient manner. This article discusses progress towards guiding treatment decisions through measuring tumour-derived factors in the circulation.

引用

页码：98 / 101

页数：4

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