Science to Practice: Opening the Blood-Brain Barrier with Focused Ultrasound-A Potential Treatment for Alzheimer Disease?

被引：7
|
作者：
Jolesz, Ferenc A. [1 ]
机构：
[1] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA
来源：
RADIOLOGY | 2014年 / 273卷 / 03期
关键词：
SURGERY;
D O I：
10.1148/radiol.14142033
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Burgess et al (1) present intriguing results of repetitive transient opening of the blood-brain barrier (BBB) in a transgenic mouse model of advanced Alzheimer disease (AD). The results underscore the potential of using magnetic resonance (MR) imaging-guided focused ultrasound and microbubble ultrasonography (US) contrast agents for the disruption of the BBB as a potential long-term therapy to reduce amyloid plaque burden and improve cognitive performance. This daring conclusion that is based on an experimental animal model should now be confirmed in humans. Considering that the technology is commercially available and given the immense clinical need, clinical trials in this AD treatment should be initiated as soon as possible.
引用
收藏
页码：631 / 633
页数：3
相关论文
共 50 条
  • [21] Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound
    Meng, Ying
    Goubran, Maged
    Rabin, Jennifer S.
    McSweeney, Melissa
    Ottoy, Julie
    Pople, Christopher B.
    Huang, Yuexi
    Storace, Alexandra
    Ozzoude, Miracle
    Bethune, Allison
    Lam, Benjamin
    Swardfager, Walter
    Heyn, Chinthaka
    Abrahao, Agessandro
    Davidson, Benjamin
    Hamani, Clement
    Aubert, Isabelle
    Zetterberg, Henrik
    Ashton, Nicholas J.
    Karikari, Thomas K.
    Blennow, Kaj
    Black, Sandra E.
    Hynynen, Kullervo
    Lipsman, Nir
    BRAIN, 2023, 146 (03) : 865 - 872
  • [22] Opening the Blood-Brain Barrier in the Substantia Nigra of Rat Brain with Focused Ultrasound and Microbubbles
    Rodriguez, J. A.
    Reyes, C. J.
    Gutierrez, M., I
    Vera, A.
    Martinez-Fong, D.
    Negreira, C.
    Leija, L.
    2019 GLOBAL MEDICAL ENGINEERING PHYSICS EXCHANGES/PAN AMERICAN HEALTH CARE EXCHANGES (GMEPE/PAHCE), 2019,
  • [23] Monitoring Blood-Brain Barrier Opening in Rats with a Preclinical Focused Ultrasound System
    Kim, Kisoo
    Gallus, Marco
    Xiao, Tianrun
    Parchure, Akshay S.
    Shah, Bhavya R.
    Okada, Hideho
    Diederich, Chris
    Ozhinsky, Eugene
    Narsinh, Kazim
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2024, (211):
  • [24] BLOOD-BRAIN BARRIER OPENING FOR TARGETED STEM CELL DELIVERY BY FOCUSED ULTRASOUND
    Grudzenski-Theis, S.
    Heger, S.
    De Jonge, A.
    Schipp, J.
    Bieback, K.
    Schad, L.
    Platten, M.
    Fatar, M.
    INTERNATIONAL JOURNAL OF STROKE, 2020, 15 (1_SUPPL) : 623 - 623
  • [25] Neuromodulation accompanying focused ultrasound-induced blood-brain barrier opening
    Po-Chun Chu
    Hao-Li Liu
    Hsin-Yi Lai
    Chung-Yin Lin
    Hong-Chieh Tsai
    Yu-Cheng Pei
    Scientific Reports, 5
  • [26] Neuromodulation accompanying focused ultrasound-induced blood-brain barrier opening
    Chu, Po-Chun
    Liu, Hao-Li
    Lai, Hsin-Yi
    Lin, Chung-Yin
    Tsai, Hong-Chieh
    Pei, Yu-Cheng
    SCIENTIFIC REPORTS, 2015, 5
  • [27] Biosynthetic Gas Vesicles Combined with Focused Ultrasound for Blood-Brain Barrier Opening
    Zhang, Jinghan
    Yan, Fei
    Zhang, Wei
    He, Lei
    Li, Yi
    Zheng, Shuai
    Wang, Yuanyuan
    Yu, Tengfei
    Du, Lijuan
    Shen, Yuanyuan
    He, Wen
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2022, 17 : 6759 - 6772
  • [28] Focused-ultrasound blood-brain barrier opening promotes neuroprotective microglia
    Kline-Schoder, Alina R.
    Chintamen, Sana
    Menon, Vilas
    Kernie, Steven G.
    Konofagou, Elisa E.
    2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS), 2022,
  • [29] Blood-Brain Barrier Opening with Focused Ultrasound in Parkinson's Disease Dementia: A Safety and Feasibility Study
    Gasca-Salas, Carmen
    Fernandez-Rodriguez, Beatriz
    Angel Pineda-Pardo, Jose
    Rodriguez-Rojas, Rafael
    Hernandez, Frida
    Obeso, Ignacio
    Mata Marin, David
    Guida, Pasqualina
    del Alamo, Marta
    Ordas Bandera, Carlos
    Rachmilevitch, Itay
    Obeso, Jose A.
    NEUROLOGY, 2020, 94 (15)
  • [30] Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease
    Mehta, Rashi, I
    Carpenter, Jeffrey S.
    Mehta, Rupal, I
    Haut, Marc W.
    Ranjan, Manish
    Najib, Umer
    Lockman, Paul
    Wang, Peng
    D'haese, Pierre-Francois
    Rezai, Ali R.
    RADIOLOGY, 2021, 298 (03) : 654 - 662
12345