Oxidative stress parameters in rats exposed to fluoride and caffeine

被引：50
|
作者：
Inkielewicz-Stepniak, I. [1 ]
Czarnowski, W. [1 ]
机构：
[1] Med Univ Gdansk, Dept Toxicol, PL-80416 Gdansk, Poland
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2010年 / 48卷 / 06期
关键词：
Fluoride and caffeine; Fluoride in urine; Nitric oxide; Total antioxidant potential; Lipid peroxidation; Male rats; LIPID-PEROXIDATION; SODIUM-FLUORIDE; SOFT-TISSUES; NITRIC-OXIDE; METABOLISM; URINE; SERUM; FLUOROSIS; CAPACITY; COFFEE;
D O I：
10.1016/j.fct.2010.03.033
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
In our experiment, the 1-month effects of caffeine (Caff) and fluoride (F) administered separately and together on nitric oxide and total antioxidant status in serum, brain, liver and kidney of rats were investigated. Also, the influence of caffeine on fluoride excretion with urine was studied. Thirty adult male Wistar rats were divided into five equal groups of six each: (I) controls drinking tap water; (II) controls drinking tap water and receiving intragastrically 0.5 ml of tap water; (III) animals receiving 25 mg F/L in drinking water; (IV) animals receiving 4.7 mg Caff/kg bw/day; (V) animals receiving 25 mg F/L in drinking water and 4.7 mg Caff/kg bw/day. The applied fluoride caused increase of nitric oxide level (NO), intensified lipid peroxidation (TBARS) and decreased total antioxidant status in serum (TAS), brain, kidney and liver. Caffeine administered intragastrically, as an antioxidant, was relatively efficient in alleviating these adverse effects of F. In rats treated only with fluoride the F excretion in urine significantly increased in an exposure-time dependent-manner and did not change both in rats treated with Caff and co-exposed to Caff and F. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1607 / 1611
页数：5
相关论文
共 50 条
  • [21] GENDER DIFFERENCES IN THE OXIDATIVE STATUS IN RATS EXPOSED TO CHRONIC STRESS
    Farias, M.
    Jimeno, M.
    Stagnoli, A.
    Bensi, N.
    Binotti, S.
    Niebylski, A.
    [J]. BIOCELL, 2013, 37 (03) : A183 - A183
  • [22] Chosen markers of oxidative stress in rats exposed to dimethoate and pyrantel
    Barski, D.
    Zasadowski, A.
    Spodniewska, A.
    [J]. TOXICOLOGY LETTERS, 2005, 158 : S181 - S181
  • [23] Oxidative stress in testes of rats exposed to n-butylparaben
    Schreiber, Elga
    Garcia, Tania
    Sharma, Raju Prasad
    Torrente, Margarita
    Domingo, Jose Luis
    Gomez, Mercedes
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2019, 131
  • [24] Oxidative Stress and Sex Difference in Liver of Rats Exposed to Cyclohexanone
    Lee, Yong-Hoon
    Lim, Cheol-Hong
    Chung, Yong Hyun
    [J]. INTERNATIONAL JOURNAL OF MORPHOLOGY, 2018, 36 (03): : 881 - 885
  • [25] OXIDATIVE STRESS INDICES IN ERYTHROCYTES, LIVER, AND KIDNEYS OF FLUORIDE-EXPOSED RABBITS
    Ranjan, R.
    Swarup, D.
    Patra, R. C.
    [J]. FLUORIDE, 2009, 42 (02) : 88 - 93
  • [26] Fluoride and oxidative stress
    Chlubek, D
    [J]. FLUORIDE, 2003, 36 (04) : 217 - 228
  • [27] Oxidative stress contributes to pulmonary hypertension in rats exposed to monocrotaline
    Chaumais, M. -C.
    Dorfmueller, P.
    Montani, D.
    Perros, F.
    Humbert, M. J. C.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181
  • [28] The influence of erythropoietin treatment on oxidative stress parameters in cortex of rats exposed to transient middle cerebral artery occlusion
    Mrsic-Pelcic, Jasenka
    Pilipovic, Kristina
    Vujicic, Bozidar
    Pelcic, Goran
    Vitezic, Dinko
    Zupan, Gordana
    [J]. PERIODICUM BIOLOGORUM, 2011, 113 (01) : 69 - 74
  • [29] Effect of sodium fluoride on neuroimmunological parameters, oxidative stress and antioxidative defenses
    Reddy, Y. P.
    Tiwari, S. K.
    Shaik, A. P.
    Alsaeed, A.
    Sultana, A.
    Reddy, P. K.
    [J]. TOXICOLOGY MECHANISMS AND METHODS, 2014, 24 (01) : 31 - 36
  • [30] Effects of primaquine and chloroquine on oxidative stress parameters in rats
    Giovanella, Francianne
    Ferreira, Gabriela K.
    De Pra, Samira D. T.
    Carvalho-Silva, Milena
    Gomes, Lara M.
    Scaini, Giselli
    Goncalves, Renata C.
    Michels, Monique
    Galant, Leticia S.
    Longareti, Luiza M.
    Dajori, Ana Luiza
    Andrade, Vanesa M.
    Dal-Pizzol, Felipe
    Streck, Emilio L.
    De Souza, Renan P.
    [J]. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2015, 87 (02): : 1487 - 1496
12345