Immunohistochemical expression of E-cadherin in salivary glands and their tumours

被引：0

作者：

Yamada, K ^{[1
]}

Speight, PM ^{[1
]}

Kudeken, W ^{[1
]}

Muramatu, Y ^{[1
]}

Sumitomo, S ^{[1
]}

Shiba, T ^{[1
]}

Mori, M ^{[1
]}

Takai, Y ^{[1
]}

机构：

[1] Asahi Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Asahikawa, Hokkaido, Japan

来源：

ORAL ONCOLOGY, VOL V | 1997年

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study aims to evaluate expression of E-cadherin in normal salivary glands and their tumors using paraffin embedded sections. In normal submandibular and parotid gland, E-cadherin staining was confined to the cell membrane of acinar and ductal cells. In pleomorphic adenoma and mucoepidermoid carcinoma, E-cadherin was positive at the lateral cell membrane or cell membrane as a whole in duct-like structures and epidermoid cells. Acinic cell carcinoma showed no E-cadherin. In adenoid cystic carcinoma, the expression was only found in cribriform areas. In adenocarcinoma, the staining was seen in the cell membrane of duct like structures and occasional cells showed a strong cytoplasmic reaction. The intensity of immunostaining for E-cadherin in salivary tumors was higher in benign tumors than in malignant tumors. The results of the present study suggest that E-cadherin is expressed in normal salivary glands and a low expression in malignant salivary tumors.

引用

页码：481 / 484

页数：4

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