Immunohistochemical expression of E-cadherin in salivary glands and their tumours

被引：0
|
作者：
Yamada, K [1 ]
Speight, PM [1 ]
Kudeken, W [1 ]
Muramatu, Y [1 ]
Sumitomo, S [1 ]
Shiba, T [1 ]
Mori, M [1 ]
Takai, Y [1 ]
机构：
[1] Asahi Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Asahikawa, Hokkaido, Japan
来源：
ORAL ONCOLOGY, VOL V | 1997年
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The present study aims to evaluate expression of E-cadherin in normal salivary glands and their tumors using paraffin embedded sections. In normal submandibular and parotid gland, E-cadherin staining was confined to the cell membrane of acinar and ductal cells. In pleomorphic adenoma and mucoepidermoid carcinoma, E-cadherin was positive at the lateral cell membrane or cell membrane as a whole in duct-like structures and epidermoid cells. Acinic cell carcinoma showed no E-cadherin. In adenoid cystic carcinoma, the expression was only found in cribriform areas. In adenocarcinoma, the staining was seen in the cell membrane of duct like structures and occasional cells showed a strong cytoplasmic reaction. The intensity of immunostaining for E-cadherin in salivary tumors was higher in benign tumors than in malignant tumors. The results of the present study suggest that E-cadherin is expressed in normal salivary glands and a low expression in malignant salivary tumors.
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页码：481 / 484
页数：4
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