Two novel abietane norditerpenoids with anti-inflammatory properties from the roots of Salvia miltiorrhiza var. alba

被引：14
|
作者：
Xie, Tingting [1 ]
Ma, Shuli [1 ]
Lou, Hongxiang [1 ]
Zhu, Rongxiu [2 ]
Sun, Longru [1 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol MOE, Dept Nat Prod Chem, Jinan 250012, Peoples R China
[2] Shandong Univ, Sch Chem & Chem Engn, Jinan 250010, Peoples R China
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 51期
基金：
中国国家自然科学基金;
关键词：
Salvia miltiorrhiza var. alba; Salvialba acid; 2-Hydroxydihydrotanshinone I; Absolute configuration; Anti-inflammatory properties;
D O I：
10.1016/j.tetlet.2014.10.153
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Salvialba acid (1) with a novel abietane norditerpenoid skeleton and 2-hydroxydihydrotanshinone I(2), a new abietane norditerpenoid, were isolated from Salvia miltiorrhiza var. alba. Their structures were elucidated by spectroscopic analysis and X-ray diffraction. The absolute configuration of 1 was determined by an electronic circular dichroism (ECD) experiment and TDDFT ECD computations. A possible biosynthesis pathway is proposed for 1. Compounds 1 and 2 were demonstrated to have anti-inflammatory effects on vascular inflammation induced by TNF-alpha in human aortic endothelial cells (HAECs). (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7106 / 7109
页数：4
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