Two novel abietane norditerpenoids with anti-inflammatory properties from the roots of Salvia miltiorrhiza var. alba

被引：14

作者：

Xie, Tingting ^{[1
]}

Ma, Shuli ^{[1
]}

Lou, Hongxiang ^{[1
]}

Zhu, Rongxiu ^{[2
]}

Sun, Longru ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol MOE, Dept Nat Prod Chem, Jinan 250012, Peoples R China

[2] Shandong Univ, Sch Chem & Chem Engn, Jinan 250010, Peoples R China

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 51期

基金：

中国国家自然科学基金;

关键词：

Salvia miltiorrhiza var. alba; Salvialba acid; 2-Hydroxydihydrotanshinone I; Absolute configuration; Anti-inflammatory properties;

D O I：

10.1016/j.tetlet.2014.10.153

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Salvialba acid (1) with a novel abietane norditerpenoid skeleton and 2-hydroxydihydrotanshinone I(2), a new abietane norditerpenoid, were isolated from Salvia miltiorrhiza var. alba. Their structures were elucidated by spectroscopic analysis and X-ray diffraction. The absolute configuration of 1 was determined by an electronic circular dichroism (ECD) experiment and TDDFT ECD computations. A possible biosynthesis pathway is proposed for 1. Compounds 1 and 2 were demonstrated to have anti-inflammatory effects on vascular inflammation induced by TNF-alpha in human aortic endothelial cells (HAECs). (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：7106 / 7109

页数：4

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