Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease

被引：21

作者：

Miyoshi, Eiji ^{[1
]}

Shinzaki, Shinichiro ^{[1
,2
]}

Fujii, Hironobu ^{[1
]}

Iijima, Hideki ^{[2
]}

Kamada, Yoshihiro ^{[1
,2
]}

Takehara, Tetsuo ^{[2
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Mol Biochem & Clin Investigat, 1-7 Yamada Oka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Suita, Osaka, Japan

来源：

PROTEOMICS CLINICAL APPLICATIONS | 2016年 / 10卷 / 04期

基金：

日本学术振兴会;

关键词：

Agalactosylation of IgG; Galectin; Glycobiomarker; Glycosylation; IBD; RHEUMATOID-ARTHRITIS; PANCREATIC-CANCER; CROHNS-DISEASE; OLIGOSACCHARIDES; COLITIS; MICE;

D O I：

10.1002/prca.201500089

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The intestine is one of the most important organs associated with the immune system. It is thought that disruption of intestinal immunity causes inflammatory bowel disease (IBD). Recent advances in immune glycobiology have provided novel insights into many human diseases. For example, studies of glycosylation remodeling in mice have underscored the importance of oligosaccharides in the pathogenesis of IBD. Furthermore, aberrant glycosylation of IgG is a good serum marker of IBD activity. In this review, we examine current understanding of the role of aberrant glycosylation in the pathogenesis of IBD in terms of our original data and recent reports.

引用

页码：384 / 390

页数：7

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